Epidron 25 mg/5 ml (Injection)

Indications

• Reversal of hypotension induced by spinal or epidural anaesthesia

Pharmacology

• Ephedrine is a stimulant drug
• Belongs to sympathomimetics group
• Alpha and beta adrenergic agonist
• Enhances release of norepinephrine
• Increases activity of central nervous system

Dosage & Administration

• Dose: 3 to 6 mg Ephedrine Hydrochloride for hypotension
• Route: Slow intravenous injection
• Repeat every 3 to 4 minutes as required
• Maximum total dose: 30 mg
• Can be given intramuscularly or subcutaneously

Interaction

• May cause hypertensive crisis in patients on MAO inhibitors
• Should be used with caution in patients on volatile anaesthetics
• Increased risk of arrhythmias in patients receiving certain medications
• Increased risk of vasoconstrictor effects in patients receiving certain medications

Contraindications

• Contraindicated in presence of coronary thrombosis
• Caution in patients with organic heart disease, hyperthyroidism, hypertension, and angina
• Caution in patients receiving digitalis

Side Effects

• Nausea, vomiting, anorexia
• Tachycardia, bradycardia, arrhythmias
• Anginal pain, hypertension, hypotension
• Dizziness, flushing
• Dyspnoea, headache, anxiety
• Restlessness, confusion, psychoses
• Insomnia, tremor
• Difficulty in micturition, urine retention
• Sweating, hypersalivation
• Changes in blood-glucose concentration
• Rarely angle-closure glaucoma

Pregnancy & Lactation

• Pregnancy Category C
• Not recommended during lactation due to risk of adverse effects in infant

Precautions & Warnings

• Caution in patients with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, or angle-closure glaucoma
• May increase difficulty with micturition in patients with prostatic enlargement
• Increased fetal heart rate reported with parenteral use
• Irritability and disturbed sleep reported in breast-fed infants

Overdose Effects

• Minor reactions in most patients
• Giddiness, headache, nausea, vomiting
• Sweating, palpitations
• Difficulty in micturition, tremors
• Anxiety, restlessness, insomnia

Therapeutic Class

• Other adrenoceptor stimulants
• Vasoconstrictor/Venotonic

Storage Conditions

• Store in a cool, dry place
• Protected from light
• Keep out of reach of children

Related Brands

• Ephidin 25 mg/5 ml (Injection) - popular-pharmaceuticals-ltd