Fedrin 25 mg/5 ml (Injection)

Indications

• Reversing hypotension induced by spinal or epidural anaesthesia

Pharmacology

• Stimulant drug
• Belongs to sympathomimetics group
• Alpha and beta adrenergic agonist
• Enhances the release of norepinephrine

Dosage & Administration

• 3 to 6 mg Ephedrine Hydrochloride for hypotension
• Given by slow intravenous injection
• Repeat every 3 to 4 minutes if necessary
• Maximum total dose is 30 mg

Interaction

• May cause hypertensive crisis in patients receiving Monoamine Oxidase Inhibitor
• To be used with care in patients undergoing anaesthesia with volatile anaesthetics
• Increased risk of arrhythmias in patients receiving specific medications
• Increased risk of vasoconstrictor or pressor effects in patients receiving ergot alkaloids or oxytocin

Contraindications

• Contraindicated in the presence of coronary thrombosis
• Caution in patients with organic heart disease, hyperthyroidism, hypertension, and angina pectoris
• Caution in patients receiving digitalis

Side Effects

• Nausea, vomiting, anorexia
• Tachycardia, bradycardia, arrhythmias
• Anginal pain, hypertension, hypotension
• Dizziness, flushing, dyspnoea
• Headache, anxiety, restlessness, confusion
• Tremor, difficulty in micturition, urine retention
• Sweating, hypersalivation, changes in blood-glucose concentration
• Rarely angle-closure glaucoma

Pregnancy & Lactation

• Category C in pregnancy
• Not recommended for use during lactation due to potential adverse effects in the infant

Precautions & Warnings

• Care in patients with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, and angle-close glaucoma
• May increase difficulty with micturition in patients with prostatic enlargement
• Increased fetal heart rate reported with parenteral usage
• Irritability and disturbed sleep reported in breast-fed infants

Overdose Effects

• Giddiness, headache, nausea, vomiting
• Sweating, palpitations, difficulty in micturition
• Tremors, anxiety, restlessness, insomnia

Therapeutic Class

• Other adrenoceptor stimulants
• Vasoconstrictor/Venotonic

Storage Conditions

• Store in a cool, dry place
• Protected from light
• Keep out of reach of children

Related Brands

• Epidron 25 mg/5 ml (Injection) - renata-limited
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