Neocliz 25 mg+50 mg (Tablet)

Indications

• Prevention and treatment of nausea
• Prevention and treatment of vomiting
• Prevention and treatment of dizziness
• Prevention and treatment of motion sickness
• Prevention and treatment of radiation sickness
• Prevention and treatment of vertigo associated with diseases of the vestibular system

Pharmacology

• Piperazine-derivative antihistamine
• Antiemetic properties
• Anticholinergic properties
• Antihistaminic properties
• Reduces sensitivity of the labyrinthine apparatus
• Action mediated through nerve pathways to the vomiting center

Dosage & Administration

• Dosing for adults and children 12 years of age and over
• Different dosages for nausea and vomiting, motion sickness, radiation sickness, and vertigo
• Dosage for prevention of nausea and vomiting associated with emergency contraceptive pill (ECP)

Interaction

• Potentiation of CNS depressant effects by ethanol or other CNS depressant agents
• Potentiation of anticholinergic effects by other anticholinergics
• Increase in digoxin absorption by decreasing gastrointestinal motility

Contraindications

• Contraindicated in patients hypersensitive to Meclizine Hydrochloride and Pyridoxine Hydrochloride

Side Effects

• Drowsiness
• Dry mouth
• Blurred vision

Pregnancy & Lactation

• Pregnancy Category B
• Suggested lowest risk of teratogenicity
• Safety for use in nursing mother not established

Precautions & Warnings

• Impairment of ability to perform hazardous activities
• Avoidance of alcoholic beverages
• Caution in patients with asthma, glaucoma, or prostate gland enlargement

Overdose Effects

• Symptoms of extreme excitability, seizures, drowsiness, and hallucinations
• Appropriate supportive and symptomatic treatment
• Consideration of dialysis

Therapeutic Class

• Anti-emetic drugs

Storage Conditions

• Storage below 30°C temperature
• Storage away from light and moisture
• Keep out of the reach of children

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