Fimoxyclav ES (600 mg+42.9 mg)/5 ml (Powder for Suspension)

Indications

• Upper respiratory tract infections
• Lower respiratory tract infections
• Genito-urinary tract infections
• Skin and soft tissue infections
• Bone and joint infections
• Septic abortion
• Puerperal sepsis
• Intra-abdominal sepsis

Composition

• 375 mg tablet
• 625 mg tablet
• 1 gm tablet
• Powder for Suspension
• Powder for Suspension (Forte)
• 1.2 gm Injection
• 0.6 gm injection

Pharmacology

• Bactericidal activity
• Broad spectrum
• Microorganism susceptibility
• Beta-lactamase inhibitor
• Antibiotic spectrum
• Peak serum levels
• Oral administration
• Absorption optimization
• Serum binding
• Doubling dosage impact

Dosage

• Tablet for adults and children over 12 years
• Suspension for children of different ages
• Forte suspension dosage
• IV Injection dosage for adults and children

Administration

• Oral dosage form
• IV injection administration
• Intravenous injection time frame

Interaction

• Prolongation of bleeding time
• Prothrombin time impact
• Efficacy reduction with oral contraceptives
• Concomitant use of allopurinol

Contraindications

• Penicillin hypersensitivity
• Cross-sensitivity with beta-lactam antibiotics
• History of cholestatic jaundice

Side Effects

• Diarrhoea
• Pseudomembranous colitis
• Indigestion
• Nausea
• Vomiting
• Candidiasis
• Hepatitis
• Cholestatic jaundice
• Rashes
• Angioedema
• Anaphylaxis

Pregnancy & Lactation

• Teratogenic effect in animal studies
• Limited human pregnancy use
• Detection in breast milk

Precautions & Warnings

• Care for patients on anticoagulation therapy
• Dosage adjustment for renal impairment
• Severe hepatic dysfunction caution
• Fluid intake and urinary output maintenance

Use in Special Populations

• Dose adjustment for renal impairment
• Hepatic impairment caution

Overdose Effects

• Unlikely occurrence
• Gastrointestinal symptoms
• Fluid and electrolyte balance disturbance
• Haemodialysis removal

Therapeutic Class

• Broad spectrum penicillins

Reconstitution

• IV injection reconstitution
• Restrictions for reconstitution and mixing

Storage Conditions

• Temperature storage
• Light and moisture protection
• Refrigeration of reconstituted suspension
• Timeframe for reconstituted vial usage

Related Brands

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• Amoclav Forte (400 mg+57.50 mg)/5 ml (Powder for Suspension) - techno-drugs-ltd