Doctil Plus (125 mg+31.25 mg)/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Cefuroxime axetil clavulanic acid |
| Company | Maks drug limited |
| Also available as |
Title
Doctil Plus 125 Syrup
Categories
- Antibiotics
- Bactericidal Medications
- Cephalosporin Antibiotics
- Beta-lactamase Inhibitors
Description
Doctil Plus 125 Syrup is indicated for the treatment of various bacterial infections caused by sensitive bacteria. It contains Cefuroxime, a second generation cephalosporin antibiotic, and Clavulanic acid, a beta-lactamase inhibitor.
DosageAndAdministration
- 250 mg b.i.d. for 5-10 days for pharyngitis/tonsillitis
- 250 mg b.i.d. for 10 days for acute bacterial maxillary sinusitis
- 250-500 mg b.i.d. for 10 days for acute bacterial exacerbation of chronic bronchitis
- 250-500 mg b.i.d. for 5-10 days for secondary bacterial infections of acute bronchitis
- 250-500 mg b.i.d. for 10 days for uncomplicated skin and skin structure infections
- 250 mg b.i.d. for 7-10 days for uncomplicated urinary tract infections
- 1000 mg b.i.d. single dose for uncomplicated gonorrhoea
- 250-500 mg b.i.d. for 5-10 days for community-acquired pneumonia
- 500 mg b.i.d. for 10-14 days for MDR typhoid fever
- 500 mg b.i.d. for 20 days for early Lyme disease in adolescents and adults
- 20 mg/kg/day b.i.d for 5-10 days for pharyngitis/tonsillitis in pediatric patients (3 months to 12 years)
- 30 mg/kg/day b.i.d for 10 days for acute otitis media in pediatric patients
- 30 mg/kg/day b.i.d for 10 days for acute bacterial maxillary sinusitis in pediatric patients
- 30 mg/kg/day b.i.d for 10 days for impetigo in pediatric patients
ModeOfAction
Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process. Clavulanic acid is a beta-lactamase inhibitor that provides protection of Cefuroxime from degradation by beta-lactamase enzymes.
Indications
- Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
- Acute Bacterial Otitis Media caused by various bacteria
- Acute bacterial maxillary sinusitis caused by specific bacteria
- Lower respiratory tract infections including pneumoniae caused by multiple bacteria
- Uncomplicated skin and skin-structure infections caused by specific bacteria
- Uncomplicated urinary tract infections caused by specific bacteria
- Bone and Joint Infections caused by Staphylococcus aureus
- Uncomplicated Gonorrhoea caused by specific bacteria
- Early Lyme Disease (erythema migrans) caused by Borrelia burgdorferi
- Septicemia caused by specific bacteria
- Meningitis caused by specific bacteria
- Switch therapy (Injectable to oral)
Interaction
Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%. Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime and tend to cancel the effect of postprandial absorption.
Contraindications
- Known allergy to cephalosporin
- Pseudomembranous Colitis
SideEffects
- Nausea
- Vomiting
- Diarrhea
- Abdominal discomfort or pain
- Renal dysfunction (Rare)
- Anaphylaxis (Rare)
- Angioedema (Rare)
- Pruritis (Rare)
- Rash (Rare)
- Serum sickness like urticaria (Rare)
PregnancyAndLactation
Cefuroxime-Clavulanic Acid can be safely used in later pregnancy to treat urinary and other infections. It is excreted into the breast milk in small quantities, so the possibility of sensitizing the infant should be kept in mind.
PrecautionsAndWarnings
Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics and who have a history of colitis.
TherapeuticClass
Second Generation Cephalosporins
StorageConditions
Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.
CommonlyAskedQuestions
- What is Doctil Plus 125 Syrup?: Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Doctil Plus 125 Syrup is indicated for the treatment of infections caused by sensitive bacteria.
- What is Doctil Plus 125 Syrup used for?: Doctil Plus 125 Syrup is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.
- How long does it take for Doctil Plus 125 Syrup to take effect?: Doctil Plus 125 Syrup starts working within 2-3 hours after taking it.
- How long do the effects of this medicine last?: The effect of Doctil Plus 125 Syrup lasts for an average duration of 4-8 hours.
- Doctil Plus 125 Syrup it safe to consume alcohol while taking this medicine?: Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is Doctil Plus 125 Syrup a habit-forming medicine?: No habit-forming tendencies were reported for Doctil Plus 125 Syrup.
- Can this medicine be taken during pregnancy?: Doctil Plus 125 Syrup is safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.
- Can Doctil Plus 125 Syrup be taken while breast-feeding?: Doctil Plus 125 Syrup is safe to use during breastfeeding. It enters into breast milk at low levels.