Omimak 20 mg (Capsule (Enteric Coated))
Medicine Details
| Category | Details |
|---|---|
| Generic | Omeprazole |
| Company | Maks drug limited |
Indications
- Gastric and duodenal ulcer
- NSAID-associated duodenal and gastric ulcer
- As prophylaxis in patients with a history of NSAID-associated duodenal and gastric ulcer
- Gastro-esophageal reflux disease
- Long-term management of acid reflux disease
- Acid-related dyspepsia
- Severe ulcerating reflux esophagitis
- Prophylaxis of acid aspiration during general anesthesia
- Zollinger-Ellison syndrome
- Helicobacter pylori-induced peptic ulcer
Pharmacology
Inhibitor of gastric acid secretion by blocking hydrogen-potassium-adenosine triphosphatase (H+/K+ ATPase) enzyme system in the gastric parietal cell. Onset of the antisecretory effect occurs within one hour, with the maximum effect occurring within two hours and inhibition of secretion lasts up to 72 hours. When discontinued, secretory activity returns gradually over 3 to 5 days.
Dosage
- For benign gastric and duodenal ulcer
- For NSAID-associated duodenal or gastric ulcer
- For gastro-esophageal reflux disease
- For long-term management of acid reflux disease
- For acid-related dyspepsia
- For prophylaxis of acid aspiration
- For Zollinger-Ellison syndrome
- For Helicobacter pylori eradication regimen in peptic ulcer disease
- For pediatric use in severe ulcerating reflux esophagitis (Child>1 year)
Administration
- Direction for use of IV Injection
- Direction for use of IV Infusion
Interaction
Decreased intragastric acidity affecting the absorption of ketoconazole. Metabolised in the liver through cytochrome P450, leading to delayed elimination of diazepam, phenytoin, and warfarin. Monitoring of patients receiving warfarin or phenytoin is recommended. Plasma concentrations of Omimak and clarithromycin are increased during concomitant administration.
Contraindications
Known hypersensitivity to omeprazole. Treatment may alleviate symptoms and delay diagnosis if malignancy is suspected in gastric ulcer.
Side Effects
- Skin rash, urticaria, and pruritus
- Photosensitivity, bullous eruption, erythema multiforme, angioedema, and alopecia
- Diarrhea and headache
- Gastrointestinal reactions like constipation, nausea/vomiting, flatulence, and abdominal pain
- Dry mouth, stomatitis, and candidiasis
- Paraesthesia
- Dizziness, light headedness, and feeling faint
- Somnolence, insomnia, and vertigo
- Reversible mental confusion, agitation, depression, and hallucinations
- Arthritic and myalgic symptoms
- Blurred vision, taste disturbance, peripheral edema, increased sweating, and more
Pregnancy & Lactation
Omeprazole can be used during pregnancy. Breast-feeding should be discontinued if the use of omeprazole is considered essential. Safety and effectiveness of omeprazole have not been established in pediatric patients less than 18 years of age.
Precautions & Warnings
- Avoid concomitant use of clopidogrel and omeprazole
- Observational studies suggest PPI therapy may be associated with an increased risk for osteoporosis-related fractures
- Atrophic gastritis has been noted occasionally in gastric corpus biopsies from patients treated long-term with omeprazole
- Concomitant use of PPIs with methotrexate may lead to methotrexate toxicities
Therapeutic Class
Proton Pump Inhibitor
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.