Ipratop 250 mcg/ml (Respirator Solution)

1 ml ampoule: ৳ 18.00 (2 x 5: ৳ 180.00)

Medicine Details

Category Details
Generic Ipratropium bromide
Company Incepta pharmaceuticals ltd

Indications

  • Treatment of reversible bronchospasm associated with COPD
  • Treatment of reversible airway obstruction in asthma
  • As bronchodilator in the treatment of chronic reversible airway obstruction in asthma and COPD including chronic bronchitis and emphysema
  • Treatment of acute reversible airway obstruction
  • Concomitant use with inhaled beta 2-agonists

Pharmacology

  • Quaternary ammonium compound with anticholinergic properties
  • Inhibition of vagal reflexes
  • Antagonizes the action of acetylcholine
  • Prevents increase in intracellular concentration of cyclic guanosine monophosphate
  • Acts on bronchial smooth muscle

Dosage

  • Adult dosage: 250-500 micrograms (1-2 ml) 3 to 4 times daily
  • 500 micrograms/2 ml for acute bronchospasm
  • Children 6-12 years: 250 micrograms (1 ml) up to a total daily dose of 1 mg (4 ml)
  • Children 0-5 years (for treatment of acute asthma only): 125-250 micrograms (0.5 ml-1 ml) up to a total daily dose of 1 mg (4 ml)
  • Usable with a range of commercially available nebulizing devices

Administration

  • Proper inhaler use for effective medication delivery
  • Supervised administration for children
  • Instructions for cleaning inhaler
  • Technique check in front of a mirror
  • Rinse mouth after each treatment

Interaction

  • Concomitant use with sympathomimetic bronchodilators, methylxanthines, steroids, and cromolyn sodium
  • No fully evaluated interaction effects with the mentioned drugs

Contraindications

  • Hypersensitivity to atropine or its derivatives
  • Hypersensitivity to Ipratropium, Atropine or its derivative
  • Hypersensitivity to soya lecithin or related food products

Side Effects

  • Common side effects: Headache, Dizziness, Cough, Dryness of mouth, Vomiting
  • Potential adverse effects: Urticaria, Tachycardia, Skin rash, Pruritus, Anaphylactic reaction, Eye pain, Nausea
  • Symptomatic adverse effects: Dry mouth, Cough, Irritation from aerosol, Headache, Nausea, Dizziness, Blurred vision, Difficulty in accommodation, Nervousness, Paresthesias, Drowsiness, Coordination difficulty, Itching
  • Life-threatening effects are rare

Pregnancy & Lactation

  • No established safety during pregnancy
  • Caution advised when administered to nursing mothers

Precautions & Warnings

  • Close medical supervision during initial dosing
  • Caution in patients with narrow-angle glaucoma, prostatic hyperplasia, bladder-outflow obstruction, or cystic fibrosis
  • Avoid aerosol contact with the eyes
  • Temporary blurring of vision or eye pain may result if aerosol is sprayed into the eyes
  • Not indicated for initial treatment of acute episodes of bronchospasm where rapid response is required

Overdose Effects

  • Acute overdosage by inhalation is unlikely
  • Inhaled dosage of 5 mg increases heart rate and palpitation
  • Single doses of 30 mg by mouth resulted in anticholinergic side effects

Therapeutic Class

  • Anticholinergic bronchodilators

Storage Conditions

  • Fresh ampoule for each dose
  • Do not store above 25°C
  • Keep the ampoule in the outer carton

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