Cycloph 1 gm/vial (IV Infusion)

1 gm vial: ৳ 700.00

Medicine Details

Category Details
Generic Cyclophosphamide
Company Eskayef pharmaceuticals ltd
Also available as
Cycloph 500 mg injection

Title

  • Cyclophosphamide Injection

Therapeutic Class

  • Cytotoxic Chemotherapy

Indications

  • Malignant lymphomas treatment
  • Hodgkin's disease treatment
  • Leukemias treatment
  • Multiple myeloma treatment
  • Neuroblastoma treatment
  • Ovarian adenocarcinoma treatment
  • Retinoblastoma treatment
  • Breast carcinoma treatment
  • Nephrotic syndrome treatment in children

Pharmacology

  • Biotransformation in the liver
  • Interference with growth of malignant cells
  • Cross-linking of tumor cell DNA

Dosage & Administration

  • Intravenous and oral dosing
  • 40 to 50 mg/kg initial dose for adults and children
  • 1 to 5 mg/kg/day oral dosing
  • Dosing adjustments based on leukocyte count and antitumor activity

Interaction

  • Metabolism increased by phenobarbital
  • Alert for combined drug actions
  • Potentiation of succinylcholine chloride effect
  • Inhibition of cholinesterase activity

Contraindications

  • Severely depressed bone marrow function
  • Previous hypersensitivity

Side Effects

  • Nausea, vomiting, anorexia
  • Hemorrhagic colitis, oral mucosal ulceration
  • Alopecia, skin rash, pigmentation changes
  • Leukopenia, thrombocytopenia, anemia
  • Hemorrhagic ureteritis, renal tubular necrosis
  • Interstitial pneumonitis, anaphylactic reactions

Pregnancy & Lactation

  • Pregnancy Category D
  • Excretion in breast milk

Precautions & Warnings

  • Monitoring in conditions like leukopenia, thrombocytopenia, impaired hepatic or renal function
  • Special attention in patients with tumor cell infiltration of bone marrow or previous cytotoxic therapy

Use in Special Populations

  • Similar safety profile in pediatric patients as in adults
  • Elderly patients may be more susceptible to toxicities

Overdose Effects

  • No specific antidote
  • Supportive management for concurrent infection, myelosuppression, or cardiac toxicity

Storage Conditions

  • Store at a temperature not exceeding 25°C
  • Protect from light and moisture
  • Do not freeze

Related Brands