Fulvest 250 mg/5 ml (IM Injection)
5 ml vial: ৳ 8,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Fulvestrant |
| Company | Eskayef pharmaceuticals ltd |
Indications
- Treatment of Hormone Receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer in postmenopausal women
- Treatment of HR-positive advanced breast cancer in postmenopausal women with disease progression following endocrine therapy
- Treatment of HR-positive, HER2-negative advanced or metastatic breast cancer in postmenopausal women in combination with ribociclib
- Treatment of HR-positive, HER2-negative advanced or metastatic breast cancer in combination with palbociclib or abemaciclib
- Treatment of breast cancer in combination with initial endocrine based therapy or following disease progression on endocrine therapy
Pharmacology
- Estrogen receptor antagonist
- Binds competitively to estrogen receptor
- Downregulates estrogen receptor protein in human breast cancer cells
- Reversible inhibitor of the growth of tamoxifen-resistant and estrogen-sensitive human breast cancer cells
- Inhibited the growth of established breast cancer xenografts
- Showed no agonist-type effects in uterotrophic assays
Dosage & Administration
- Administered intramuscularly into the buttocks
- Slow administration
- Recommended dose for patients with moderate hepatic impairment
- Monthly administration
- Pediatric use safety and effectiveness not established
Interaction
- No known drug-drug interactions
- Metabolized by CYP 3A4
- Studied drug interaction with ketoconazole and rifampin
- No dose adjustment needed with CYP 3A4 inhibitors or inducers
Side Effects
- Common adverse reactions
- Injection site pain
- Nausea
- Bone pain
- Arthralgia
- Headache
- Back pain
- Fatigue
- Hot flash
- Vomiting
- Anorexia
- Asthenia
- Musculoskeletal pain
- Cough
- Dyspnea
- Constipation
- Increased hepatic enzymes
Pregnancy & Lactation
- No available data in pregnant women
- No information on presence in human milk or effects on breastfed infant
- Pregnancy risk
- Effect on milk production
Precautions & Warnings
- Use with caution in patients with bleeding diatheses, thrombocytopenia, or anticoagulant use
- Increased exposure in patients with hepatic impairment
- Use caution at injection site due to proximity to sciatic nerve
- Embryo-fetal toxicity
- Interference with estradiol measurement
Overdose Effects
- Limited human experience
- No adverse reactions in healthy volunteers
- Peak plasma concentrations
- Unknown potential toxicity in cancer patients
- No specific treatment
- General supportive measures
- Symptomatic treatment
Storage Conditions
- Refrigerate 2°C-8°C
- Store in the original carton to protect from light