Lipicon EZ 20 mg+10 mg (Tablet)

Indications

• Therapy with lipid-altering agents
• Individuals at significantly increased risk for atherosclerotic vascular disease
• Hypercholesterolemia
• Reducing elevated total cholesterol
• Reduction of low density lipoprotein cholesterol
• Apolipoprotein B reduction
• Reducing triglycerides
• Increasing high-density lipoprotein cholesterol
• Mixed hyperlipidemia

Pharmacology

• Atorvastatin lowers plasma cholesterol
• Inhibiting HMG-CoA reductase and cholesterol synthesis
• Increasing hepatic LDL receptors
• Ezetimibe reduces blood cholesterol
• Inhibiting absorption of cholesterol by the small intestine
• Molecular target of ezetimibe - sterol transporter NPC1L1
• Mechanism of ezetimibe in reducing hepatic cholesterol stores

Dosage & Administration

• Dosage range: 10/10 mg to 80/20 mg daily
• Recommended starting dose: 10/10 mg or 20/10 mg daily
• Administration as a single dose at any time of the day
• Recommended starting dose for patients requiring larger reduction in LDL-C: 40/10 mg daily
• Dosage for patients with homozygous familial hypercholesterolemia: 40/10 mg or 80/10 mg daily
• Dosage for patients with hepatic impairment
• Dosage for patients with renal impairment

Interaction

• Risk of myopathy during treatment with statins
• Concurrent administration of fibric acid derivatives
• Interaction with lipid-modifying doses of niacin
• Concurrent administration with cyclosporine and strong CYP3A4 inhibitors
• Interaction with gemfibrozil and niacin
• Monitoring for patients taking digoxin

Contraindications

• Active liver disease
• Unexplained persistent elevations of hepatic transaminase levels
• Hypersensitivity to any component of the preparation

Side Effects

• Rhabdomyolysis
• Myopathy
• Liver enzyme abnormalities
• Myalgia
• Abdominal pain

Pregnancy & Lactation

• Category X medication
• Contraindicated in women who are or may become pregnant
• Suggested discontinuation of lipid-lowering drugs during pregnancy
• Uncertain excretion of atorvastatin in human milk

Precautions & Warnings

• Risk of myopathy and rhabdomyolysis
• Temporary withholding or discontinuation in patients with myopathy
• Liver enzyme tests prior to initiating therapy
• Caution with drugs decreasing levels or activity of endogenous steroid hormones

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No dosage adjustment necessary in geriatric patients

Overdose Effects

• No specific treatment recommended
• Symptomatic treatment
• Supportive measures

Therapeutic Class

• Other lipid regulating drugs

Storage Conditions

• Do not store above 30°C
• Store in a dry place
• Protect from light
• Keep out of the reach of children

Related Brands

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