Ranovent ER 500 mg (Tablet (Extended Release))

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Ranolazine
Company Ibn sina pharmaceuticals ltd

Indications

  • Treatment of chronic angina
  • Decrease angina episodes
  • Used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy
  • Lipid-lowering therapy
  • ACE inhibitors
  • Angiotensin receptor blockers
  • Maximal doses of amlodipine

Pharmacology

  • Anti-ischemic effects
  • Antianginal effects
  • Inhibition of cardiac late sodium current (I Na)
  • QT prolongation effect
  • Inhibition of I Kr
  • Absorption: C max 2-5 h
  • Half-life: 6-22 h
  • Distribution: 62% bound to human plasma proteins
  • Metabolized by CYP3A and CYP2D6
  • Metabolized in the liver and intestine
  • Excretion in urine and feces

Dosage & Administration

  • Initiate dosing at 500 mg twice daily
  • Increase to 1000 mg twice daily if needed
  • Take with or without meals
  • Swallow tablets whole

Interaction

  • CYP 3A Inhibitors
  • CYP 3A Inducers
  • P-gp Inhibitors (e.g., Cyclosporin)
  • Drugs transported by P-gp or metabolized by CYP2D6

Contraindications

  • Pre-existing QT prolongation
  • Hepatic impairment
  • Taking QT prolonging drugs
  • Taking potent and moderately potent CYP3A inhibitors

Side Effects

  • Cardiac Disorders: bradycardia, palpitations
  • Ear and Labyrinth Disorders: tinnitus, vertigo
  • Gastrointestinal Disorders: abdominal pain, dry mouth, vomiting
  • Peripheral edema
  • Respiratory, Thoracic, and Mediastinal Disorders: dyspnea
  • Vascular Disorders: hypotension, orthostatic hypotension

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate studies assessing the effect on the fetus
  • No well-controlled studies in pregnant women
  • Excretion in human milk
  • Potential risk to the fetus
  • Potentiality for serious adverse reactions in nursing infants

Precautions & Warnings

  • Blocks QTc and prolongs the QTc interval
  • No increased risk of proarrhythmia or sudden death
  • Co-administration with digoxin
  • Increases the plasma concentrations of digoxin
  • Caution when co-administering with P-gp inhibitors

Overdose Effects

  • Dose-related increases in dizziness, nausea, and vomiting
  • Diplopia
  • Paresthesia
  • Confusion
  • Syncope
  • Continuous ECG monitoring
  • Hemodialysis is unlikely to be effective

Therapeutic Class

  • Other Anti-anginal & Anti-ischemic drugs

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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