Renexin XR 500 mg (Tablet (Extended Release))

Unit Price: ৳ 16.00 (3 x 10: ৳ 480.00)
Strip Price: ৳ 160.00

Medicine Details

Category Details
Generic Ranolazine
Company Opsonin pharma ltd

Title

  • Renexin ER

Categories

  • Medicine
  • Pharmaceutical

Description

  • Renexin ER is a medication indicated for the treatment of chronic angina. It may be used with beta-blockers, nitrates, calcium channel blockers, anti-platelet therapy, lipid-lowering therapy, ACE inhibitors, and angiotensin receptor blockers. It has been shown to decrease angina episodes in patients with coronary artery disease.

Brand Name

Renexin ER

Indications

  • Treatment of chronic angina
  • Decrease in angina episodes
  • Use with other antianginal drugs

Pharmacology

  • Anti-ischemic effects
  • Anti-anginal effects
  • Inhibition of cardiac late sodium current
  • Prolongation of QT interval
  • Metabolism by CYP3A
  • Metabolism in liver and intestine

Dosage & Administration

  • Initiate at 500mg twice daily
  • Maximum recommended daily dose of 1000mg twice daily
  • Swallow whole, do not crush or chew
  • Contraindicated in pediatric patients

Interactions

  • Strong CYP 3A inhibitors
  • Moderate CYP 3A inhibitors
  • P-gp inhibitors
  • Drugs transported by P-gp or metabolized by CYP2D6

Contraindications

  • Pre-existing QT prolongation
  • Hepatic impairment
  • Taking QT prolonging drugs
  • Taking potent CYP3A inhibitors

Side Effects

  • Bradycardia
  • Palpitations
  • Tinnitus
  • Vertigo
  • Abdominal pain
  • Dry mouth
  • Dyspnea
  • Hypotension
  • Peripheral edema

Pregnancy & Lactation

  • Pregnancy Category C
  • No adequate studies in pregnant women
  • Potential risk to the fetus
  • Use during pregnancy justified by potential benefit
  • Unknown excretion in human milk
  • Consideration for nursing mothers

Precautions & Warnings

  • Blocks QTc interval
  • Prolongs QTc interval
  • No increased risk of proarrhythmia or sudden death
  • Co-administration with digoxin
  • Caution with P-gp inhibitors

Overdose Effects

  • Dose-related increases in dizziness, nausea, and vomiting
  • Diplopia
  • Paresthesia
  • Continuous ECG monitoring may be warranted
  • Hemodialysis unlikely to be effective

Therapeutic Class

  • Other Anti-anginal & Anti-ischemic drugs

Storage Conditions

  • Below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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