Sinatide 50 mcg+250 mcg (Inhalation Capsule)

Therapeutic Class

• Long-acting selective β-adrenoceptor stimulants
• Respiratory corticosteroids

Indications

• Regular treatment of asthma
• Combination product for inadequately controlled asthma
• Combination product for adequately controlled asthma

Pharmacology

• Salmeterol Xinafoate: selective, long-acting beta-2 agonist
• Fluticasone Propionate: corticosteroid with mainly glucocorticoid activity
• Mechanism of action explanation

Dosage

• Different dosage for adults, adolescents, and children
• Inhaler dosage instructions
• Inhalation capsule dosage instructions
• Maxhaler dosage instructions
• Dosage for COPD
• Instructions for special patient groups

Administration

• Proper inhaler use
• Steps for effective inhaler usage
• Instructions for cleaning inhaler

Interaction

• Avoidance of non-selective and selective β-blockers
• Potential interactions with strong CYP3A4 inhibitors

Contraindications

• Hypersensitivity to salmeterol xinafoate
• Hypersensitivity to fluticasone propionate
• Contraindicated in primary treatment of status asthmaticus

Side Effects

• Adverse reactions associated with each compound
• Specific adverse events for Salmeterol
• Specific adverse events for Fluticasone Propionate

Pregnancy & Lactation

• Consideration for use during pregnancy
• Consideration for use during lactation
• Reproductive toxicity studies

Precautions & Warnings

• Use in asthma patients
• Asthma-related adverse events
• Paradoxical Bronchospasm
• Use in COPD patients
• Effects of corticosteroids
• Impact on growth velocity in pediatric patients

Use in Special Populations

• Potential reduction in growth velocity in pediatric patients

Overdose Effects

• Signs and symptoms of Salmeterol overdose
• Signs and symptoms of Fluticasone Propionate overdose

Storage Conditions

• Instructions for pressurised canister
• Storage temperature and precautions

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