Zoline 2 mg/ml (IV Infusion)
300 ml solution: ৳ 440.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linezolid |
| Company | Ibn sina pharmaceuticals ltd |
| Also available as |
Title
- Zoline
Categories
- Medicine
- Antibiotic
- Therapeutic
Description
- Zoline is indicated for the treatment of nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infection including diabetic foot infections, and uncomplicated skin and skin structure infections.
- It is also indicated for vancomycin-resistant Enterococcus faecium infections.
- Linezolid, the active ingredient in Zoline, is a synthetic antibacterial agent belonging to the oxazolidinones class of antibiotics.
- It has in vitro activity against Gram-positive aerobic bacteria, some Gram-positive anaerobic bacteria, and certain Gram-negative bacteria.
- Linezolid selectively inhibits bacterial protein synthesis via a mechanism of action different from that of other antibacterial agents.
- The recommended dosage for Zoline tablets and IV infusion varies based on the type of infection and the age of the patient.
- Zoline exhibits drug interactions with medication, resulting in potential enhancement of the pressor response to certain agents.
- It also has interactions with food, as patients are advised to avoid large quantities of foods or beverages with high tyramine content while taking Zoline.
- Zoline is contraindicated for use in patients with known hypersensitivity to Linezolid or any of the other product components.
- It should not be used in patients taking medication that inhibits monoamine oxidases A or B, or within two weeks of taking such medication.
- Patients with uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome, or those taking certain sympathomimetic agents should also avoid Zoline.
- The most common adverse events in patients treated with Zoline are diarrhea, headache, and nausea.
- Linezolid use during pregnancy should be considered only if the potential benefit justifies the potential risk to the fetus, and its presence in breast milk should be taken into account for lactating women.
- Precautions include monitoring complete blood counts, prompt ophthalmic evaluation in case of visual impairment symptoms, and careful consideration of a medical history for Clostridium difficile-associated diarrhea.
- No cases of Zoline overdose have been reported, and symptomatic and supportive care is advised for any potential overdose effects.
- The therapeutic class of Zoline is macrolides, and it is available in both oral suspension and intravenous injection forms.
- The storage conditions for Zoline formulations require room temperature storage away from light and moisture, and all medicines should be kept away from children.
Attributes
- Indications:
- Nosocomial pneumonia
- Community-acquired pneumonia
- Complicated skin and skin structure infection
- Uncomplicated skin and skin structure infections
- Vancomycin-resistant Enterococcus faecium infections
- Pharmacology:
- In vitro activity against Gram-positive aerobic bacteria
- In vitro activity against some Gram-positive anaerobic bacteria
- In vitro activity against certain Gram-negative bacteria
- Selective inhibition of bacterial protein synthesis
- Binding to the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome
- Dosage & Administration:
- Recommended daily dosage for Linezolid tablets and IV infusion
- Oral route administration with or without food
- Intravenous infusion over a period of 30 to 120 minutes
- Different dosages for pediatric patients and adults
- Recommended duration of treatment for different infections
- No dose adjustment necessary when switching from intravenous to oral administration
- Hepatic impairment dosage recommendations
- Use in neonates and pediatric patients
- Inspection and precautions for intravenous administration
- Interaction:
- Drug interaction with medication
- Potential enhancement of the pressor response to certain agents
- Avoidance of large quantities of foods or beverages with high tyramine content
- Contraindications:
- Known hypersensitivity to Linezolid or other product components
- Concurrent use with medication that inhibits monoamine oxidases A or B
- Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis
- Concurrent use with sympathomimetic agents, vasopressive agents, and dopaminergic agents
- Side Effects:
- Most common adverse events: diarrhea, headache, nausea
- Other adverse events: oral moniliasis, vaginal moniliasis, hypertension, dyspepsia, localized abdominal pain, pruritus, tongue discoloration
- Pregnancy & Lactation:
- Potential benefit justifying potential risk during pregnancy
- Presence of Linezolid in breast milk
- Consideration of developmental and health benefits of breastfeeding
- Precautions & Warnings:
- Monitoring of complete blood counts
- Prompt ophthalmic evaluation in case of visual impairment symptoms
- Careful consideration of a medical history for Clostridium difficile-associated diarrhea
- Overdose Effects:
- No reported cases of overdose
- Symptomatic and supportive care advised if overdose occurs
- Therapeutic Class:
- Macrolides
- Reconstitution:
- Shaking the bottle to loosen powder
- Adding boiled and cooled water to the dry mixture
- Shaking the suspension well before each use
- Storage considerations for the reconstituted suspension
- Storage Conditions:
- Room temperature storage
- Away from light and moisture
- Keeping all medicines away from children