Azithron 500 mg (Capsule)

Title

• Azithron 500 mg Capsule

Categories

• Antibiotic
• Medication
• Pharmaceutical

Description

• Azithron is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue
• Treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis
• Acid-stable and can be taken orally with no need of protection from gastric acids
• Greater absorption on an empty stomach
• High concentration in phagocytes, actively transported to the site of infection
• Half-life allows a large single dose to maintain bacteriostatic levels for several days
• Acts by binding to the 50S ribosomal subunit of susceptible microorganisms
• Recommended dosage for adults and children
• Reconstitution procedure of suspension
• Interactions with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, terfenadine
• Contraindications for patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives, and hepatic diseases
• Low incidence of side-effects, mostly gastrointestinal in origin
• Pregnancy Category B, caution in use during pregnancy and lactation
• Rare serious allergic reactions reported, caution in renal impairment, avoidance in hepatic impairment
• No data on overdosage, typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea
• Storage in a dry place away from light and heat

Indication

• Lower respiratory tract infections including bronchitis and pneumonia
• Upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis
• Otitis media
• Skin and soft tissue infections
• Sexually transmitted diseases in men and women: non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis

Pharmacology

• Acid-stable and can be taken orally with no need of protection from gastric acids
• Greater absorption on an empty stomach
• High concentration in phagocytes, actively transported to the site of infection
• Half-life allows a large single dose to maintain bacteriostatic levels for several days
• Acts by binding to the 50S ribosomal subunit of susceptible microorganisms
• High concentration in tissues, over 50 times higher than in plasma
• Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination
• Azithromycin's action against various microorganisms

Dosage

• Oral dosage for adults: 500 mg once daily for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days
• Oral dosage for children based on body weight
• Azithromycin injection for IV infusion: Recommended dose for adult patients with community-acquired pneumonia

Administration

• Reconstitution procedure of suspension
• Azithromycin should be taken at least 1 hour before or 2 hours after meal

Interaction

• Interactions with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, terfenadine

Contraindications

• Hypersensitivity to Azithromycin or any other macrolide antibiotic
• Co-administration of ergot derivatives
• Patients with hepatic diseases

Side Effects

• Mostly gastrointestinal in origin
• Nausea, abdominal discomfort, vomiting, flatulence, diarrhea, loose stools
• Allergic reactions such as rash or photosensitivity
• Reversible elevations in liver transaminases
• Cholestatic jaundice observed rarely
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment seen in some patients

Pregnancy & Lactation

• Pregnancy Category B
• No adequate and well-controlled studies in pregnant women
• Caution advised during pregnancy and lactation

Precautions & Warnings

• Rare serious allergic reactions reported
• Caution in renal impairment
• Avoidance in hepatic impairment

Overdose Effects

• No data on overdosage
• Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea

Storage Conditions

• Keep in a dry place away from light and heat

Chemical Structure

• Molecular Formula: C38H72N2O12

Commonly Asked Questions

• Information about Azithron 500 mg Capsule

Related Brands

• Azithron 200 mg/5 ml (Powder for Suspension) - albion-laboratories-limited