Dylin 200 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Metronidazole
Company Albion laboratories limited

Brand

Dylin 200 mg/5 ml Suspension

Categories

  • Antibiotic
  • Antiprotozoal
  • Amoebicide
  • Antidiarrheal

DosageForm

Tablet, Suspension, Vaginal Gel, Suppository, IV Infusion

DosageAdministration

  • TrichomoniasisAdultsChildren10yrs:
    • 200 mg tid or 400 mg bid for 7 days
    • 800 mg in the morning and 1-2 gm at night for 2 days
    • 2 gm as a single dose for 1 day
  • TrichomoniasisChildren:
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
  • IntestinalAmoebiasisAdultsChildren10yrs: 800 mg tid for 5 days
  • IntestinalAmoebiasisChildren:
    • Children 7-10 yrs: 400 mg tid
    • Children 3-7 yrs: 200 mg qid
    • Children 1-3 yrs: 200 mg tid
  • ExtraIntestinalAsymptomaticAmoebiasisAdultsChildren10yrs: 400-800 mg tid for 5-10 days
  • ExtraIntestinalAsymptomaticAmoebiasisChildren:
    • Children 7-10 yrs: 200-400 mg tid
    • Children 3-7 yrs: 100-200 mg qid
    • Children 1-3 yrs: 100-200 mg tid
  • GiardiasisAdultsChildren10yrs: 2 gm once daily for 3 days
  • GiardiasisChildren:
    • Children 7-10 yrs: 1 gm once daily
    • Children 3-7 yrs: 600-800 mg once daily
    • Children 1-3 yrs: 500 mg once daily
  • AcuteUlcerativeGingivitisAdultsChildren10yrs: 200 mg tid for 3 days
  • AcuteUlcerativeGingivitisChildren:
    • Children 7-10 yrs: 100 mg tid
    • Children 3-7 yrs: 100 mg bid
    • Children 1-3 yrs: 50 mg tid
  • AcuteDentalInfectionsAdultsChildren10yrs: 200 mg tid for 3-7 days
  • BacterialVaginosisAdultsChildren10yrs:
    • 400 mg bid for 7 days
    • 2 gm as a single dose for 1 day
  • LegUlcersPressureSoresAdultsChildren10yrs: 400 mg tid for 7 days
  • AnaerobicInfectionsAdultsChildren10yrs: 800 mg initially and then 400 mg tid for 7 days
  • AnaerobicInfectionsChildren: Children 1-10 yrs: 7.5 mg/kg tid
  • SurgicalProphylaxisAdultsChildren10yrs: 400 mg tid started 24 hours before surgery for 1 day
  • SurgicalProphylaxisChildren: Children 1-10 yrs: 7.5 mg/kg tid
  • VaginalGel: One applicator full intravaginally once or twice a day for 5 days
  • SuppositoryAnaerobicInfections:
    • Adults: 1 g every 8 hours for 3 days, then 1 g every 12 hours
    • Children: 5-10 years: 500 mg every 8 hours for 3 days, then every 12 hours, Over 10 years adult dose
  • SuppositorySurgicalProphylaxis:
    • Adults: 1 g 2 hours before surgery; up to 3 further doses of 1 g may be given every 8 hours for high risk procedures
    • Children: 5-10 years: 500 mg 2 hours before surgery; up to 3 further doses of 500 mg may be given every 8 hours for high risk procedures
  • IVInfusionAdultsChildren12yrs: Infuse 500 mg 8 hourly at a rate of 5 ml/minute, maximum of 4 g should not be exceeded during a 24-hour period

Pharmacology

  • MechanismOfAction: Member of the imidazole class, classified therapeutically as an antiprotozoal agent, the 5-nitro group is reduced by anaerobes metabolically and interacts with DNA for bactericidal action

Indications

  • Post-operative infections due to anaerobic bacteria
  • Septicaemia
  • Bacterial vaginosis
  • Amoebiasis
  • Giardiasis
  • Gingivitis
  • Ulcers and pressure sores
  • Dental infections
  • Pseudomembranous colitis
  • Urogenital trichomoniasis

Interactions

  • Disulfiram
  • Alcohol
  • Warfarin
  • Lithium
  • Cyclosporin
  • Phenytoin
  • 5-Fluorouracil
  • Busulfan

Contraindications

Hypersensitivity to Metronidazole or other Nitroimidazole derivatives

SideEffects

  • Metallic taste
  • Nausea
  • Vomiting
  • Diarrhoea
  • Drowsiness
  • Rashes

PregnancyLactation

FDA Category B, caution during pregnancy and breastfeeding

PrecautionsWarnings

  • Regular hematological tests for extended use
  • Caution in hepatic encephalopathy patients
  • Darkening of urine may occur

SpecialPopulations

  • HepaticImpairment: Reduced daily dosage, caution in hepatic encephalopathy patients, urine darkening warning
  • RenalImpairment: No need for dosage reduction, metabolites retention in renal failure, efficient removal during haemodialysis, re-administration after dialysis

OverdoseEffects

  • Effects: Vomiting, ataxia, slight disorientation
  • Treatment: Symptomatic and supportive treatment

TherapeuticClass

  • Amoebicides
  • Antidiarrhoeal
  • Antiprotozoal

StorageConditions

Store below 30°C, protected from light, out of reach of children, do not use after expiry date

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