Fexoril 30 mg/5 ml (Oral Suspension)

Brand name

Fexoril

Therapeutic class

Non-sedating antihistamines

Dosage forms

• Tablet
• Suspension

Indications

• Seasonal allergic rhinitis
• Perennial allergic rhinitis
• Chronic idiopathic urticaria

Relief of symptoms

• Sneezing
• Rhinorrhea
• Lacrimation
• Itchy, red eyes
• Itchy nose/palate/throat
• Pruritus
• Number of wheals

Age groups

• Adults
• Children 2-6 years
• Children 6-11 years
• Children 12 years and older

Dosage recommendations

• Allergic rhinitis:
  • Adults and children 12 years and older:
    • 60 mg twice daily
    • 120 mg once daily
    • 180 mg once daily
  • Children 6 to 11 years:
    • 30 mg twice daily
    • 60 mg once daily
  • Children 2 to 11 years:
    • 30 mg or 5 ml suspension twice daily
• Chronic idiopathic urticaria:
  • Adults and children 12 years and older:
    • 60 mg twice daily
    • 120 mg once daily
    • 180 mg once daily
  • Children 6 to 11 years:
    • 30 mg twice daily
    • 60 mg once daily
  • Children 6 months to less than 2 years:
    • 15 mg or 2.5 ml suspension twice daily
  • Children 2 to 11 years:
    • 30 mg or 5 ml suspension twice daily

Pharmacology

Fexofenadine is an inverse agonist of the H1 histamine receptor, stabilizing the inactive form and preventing its activation. It has selective affinity for H1 receptors and does not have significant CNS effects.

Interactions

• Erythromycin
• Ketoconazole
• Omeprazole
• Antacids containing aluminium and magnesium hydroxide

Contraindications

• Known hypersensitivity to Fexofenadine Hydrochloride or any of its ingredients

Pregnancy lactation

• Pregnancy: Should not be used unless clearly necessary
• Lactation: Not recommended

Precautions warnings

• Elderly and impairments: Limited data in older people and renally or hepatically impaired patients. Careful administration in these special groups.
• Cardiovascular disease: Patients with a history of or ongoing cardiovascular disease should be warned about possible adverse reactions like tachycardia and palpitations.

Special populations

• Renal and hepatic impaired: Altered pharmacokinetics, dose adjustment recommended for renal impairment, minimal effect in hepatic disease.
• Elderly patient: Altered pharmacokinetics in individuals over 65 years of age.

Side effects

• Common:
  • Headache
  • Drowsiness
  • Dizziness
  • Nausea
• Uncommon:
  • Fatigue
• Post marketing surveillance:
  • Hypersensitivity reactions
  • Insomnia
  • Nervousness
  • Tachycardia
  • Palpitations
  • Diarrhea
  • Rash
  • Urticaria
  • Pruritus

Overdose effects

• Dizziness
• Fatigue
• Dry mouth
• Symptomatic and supportive treatment recommended

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical structure

• Molecular formula: C32H39NO4
• Chemical image: https://medex.com.bd/storage/res/g-res-468-fexofenadine-hydrochloride-chemical-structure-HrM3XW8ofnGVhLdcBRox.svg

Commonly asked questions

• Whatis: An antihistamine that blocks histamine during allergic reactions.
• Uses: Treatment of runny nose, itching eyes/nose, sneezing, hives, and itching.
• Side effects: Vomiting, Headache, Coughing, Diarrhea, Painful menstruation, Hives, Swelling of face, lips, etc.
• Storage and disposal: Kept in a cool dry place, unreachable to children and pets.
• Sedation: Can cause sleepiness.
• Overdose: Adverse reactions like dizziness, drowsiness, fatigue, and dry mouth.
• Onset of action: Starts working within 1 hour.
• Relieves symptoms: Outdoor and indoor allergies, watery eyes, runny nose, and sneezing.
• Cope with dizziness: Rest, caution with machinery, doctor if extreme dizziness.
• Antacids interaction: Decreased absorption if used together.
• Dose administration: As recommended by the doctor, avoiding overdose.
• Avoid foods drinks: Avoid grapefruit, orange, and apple juices.
• Heart problems: Caution for those with heart disorders.

Related Brands

• Fexonor 180 mg (Tablet) - osl-pharma-limited
• Fexonor 120 mg (Tablet) - osl-pharma-limited