Mimoxclav 500 mg+125 mg (Tablet)

Unit Price: ৳ 30.00 (6 x 4: ৳ 720.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Albion laboratories limited

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Genito-urinary tract infections
  • Skin and soft tissue infections
  • Bone and joint infections
  • Other infections

Composition

  • 375 mg tablet: Amoxicillin 250 mg, Clavulanic Acid 125 mg
  • 625 mg tablet: Amoxicillin 500 mg, Clavulanic Acid 125 mg
  • 1 gm tablet: Amoxicillin 875 mg, Clavulanic Acid 125 mg
  • Powder for Suspension: Amoxicillin 125 mg, Clavulanic Acid 31.25 mg
  • Powder for Suspension (Forte): Amoxicillin 400 mg, Clavulanic Acid 57.5 mg
  • 1.2 gm Injection: Amoxicillin 1 gm, Clavulanate Potassium 200 mg
  • 0.6 gm injection: Amoxicillin 500 mg, Clavulanate Potassium 100 mg

Pharmacology

  • Pharmacodynamic properties: Antibacterial combination of Amoxicillin and Clavulanic Acid
  • Pharmacokinetic properties: Closely matched pharmacokinetics of both components

Dosage

  • Adults and children over 12 years:
    • Tablet: 625 mg every 12 hours or 375 mg every 8 hours
    • Suspension: 2-3 teaspoonful every 8 hours
    • Forte suspension: 25/3.6 mg/kg/day in mild to moderate infections
    • IV Injection: 1.2 gm every 8 hours

Administration

  • Oral dosage form without regard to meals
  • IV injection over 2 minutes or slow intravenous infusion over 30 minutes

Interaction

  • Prolongation of bleeding time and prothrombin time
  • Reduction of efficacy of oral contraceptives
  • Potential interaction with allopurinol

Contraindications

  • History of Penicillin hypersensitivity
  • Cross-sensitivity with other beta-lactam antibiotics
  • Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Diarrhoea
  • Pseudomembranous colitis
  • Indigestion
  • Nausea
  • Vomiting
  • Candidiasis
  • Hepatitis
  • Cholestatic jaundice
  • Urticarial and erythematous rashes
  • Angioedema
  • Anaphylaxis

Pregnancy & Lactation

  • Animal studies: No teratogenic effect
  • Use in pregnancy: Not recommended unless essential
  • Lactation: Trace quantities of Amoxicillin in breast milk

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy
  • Adjust dosage in patients with renal impairment
  • Maintain adequate fluid intake and urinary output during high dose administration

Use in Special Populations

  • Dose adjustment for patients with renal impairment
  • Hepatic function monitoring
  • Reduction in dosage for children and hepatic impairment

Overdose Effects

Unlikely to occur, may cause gastrointestinal symptoms and electrolyte imbalance

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection reconstituted with 20 ml Water for Injection BP

Storage Conditions

Store below 25°C, protect from light and moisture; Refrigerate reconstituted suspension and use within 7 days

Related Brands