Rinase 250 mcg/ml (Respirator Solution)

Indications

• Treatment of reversible bronchospasm associated with chronic obstructive pulmonary disease (COPD)
• Treatment of reversible airway obstruction in acute and chronic asthma

Pharmacology

• Quaternary ammonium compound with anticholinergic properties
• Inhibition of vagal reflexes
• Antagonism of acetylcholine action
• Prevention of increase in intracellular concentration of cyclic GMP

Dosage

• Nebuliser Solution:
  • Adults and children over 12 years of age: 250-500 micrograms 3 to 4 times daily
  • For treatment of acute bronchospasm: 500 micrograms/2 ml
  • Children 6-12 years of age: 250 micrograms up to a total daily dose of 1 mg
  • Children 0-5 years of age: 125-250 micrograms up to a total daily dose of 1 mg
• Inhaler:
  • Adults: 1-2 puffs three or four times daily
  • Children 6-12 years: 1-2 puffs two to three times daily
  • Children below 6 years: 1 puff three times daily

Administration

• Nebuliser Solution: Should be administered using a range of commercially available nebulizing devices. Solution should be used as soon as possible after mixing. Should be administered no more frequently than 6 hourly in children under 5 years of age.
• Inhaler: Correct and regular use is crucial to prevent or lessen the severity of asthma attacks. Cleaning instructions included.

Interaction

• Rinase has been used concomitantly with sympathomimetic bronchodilators, methylxanthines, steroids and cromolyn sodium without adverse drug reactions.

Contraindications

• Known hypersensitivity to atropine or its derivatives
• Known hypersensitivity to Ipratropium, Atropine or its derivative
• Contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean, lecithin and peanut

Side Effects

• Nebuliser Solution:
  • Headache
  • Dizziness
  • Cough
  • Inhalation induced bronchospasm
  • Dryness of mouth
  • Vomiting
  • Urticaria
  • Tachycardia
  • Skin rash
  • Pruritus
• Inhaler:
  • Dry mouth
  • Cough
  • Exacerbation of symptoms
  • Irritation from aerosol
  • Headache
  • Nausea
  • Dizziness
  • Blurred vision/difficulty in accommodation

Pregnancy & Lactation

Safety during human pregnancy has not been established. Caution should be exercised when administered to nursing mothers.

Precautions & Warnings

• Nebuliser Solution: Use should be subject to close medical supervision during initial dosing. Caution advocated in patients with narrow-angle glaucoma, prostatic hyperplasia, bladder-outflow obstruction, or cystic fibrosis. Ocular complications may occur if solution/mist comes into contact with the eyes.
• Inhaler: Temporary blurring of vision, precipitation or worsening of narrow-angle glaucoma, or eye pain may result if aerosol is sprayed into the eyes. Immediate hypersensitivity reactions may occur.

Overdose Effects

Acute overdosage by inhalation is unlikely. Inhaled dosage of 5 mg produces an increase in heart rate and palpitation.

Therapeutic Class

Anticholinergic bronchodilators

Storage Conditions

Do not store above 25°C. Keep the ampoule in the outer carton.

Related Brands

• Ipramid 250 mcg/ml (Respirator Solution) - beximco-pharmaceuticals-ltd