Telisa Plus 80 mg+12.5 mg (Tablet)

Indications

• Treatment of hypertension
• Lowering blood pressure
• Reduction of risk of cardiovascular events
• Reduction of stroke risk
• Reduction of myocardial infarction risk

Pharmacology

• Telmisartan mechanism of action
• Hydrochlorothiazide mechanism of action
• Blockade of angiotensin II receptor
• Effects on renin-angiotensin system
• Thiazide diuretic action

Dosage & Administration

• Initial dosage recommendation
• Telmisartan monotherapy dosage
• Hydrochlorothiazide monotherapy dosage
• Titration dosage guidelines
• Administration with other antihypertensive drugs

Interaction

• Caution with aliskiren
• Caution with digoxin
• Caution with lithium
• Caution with NSAIDs
• Caution with corticosteroids

Contraindications

• Hypersensitivity contraindication
• Contraindication for co-administration with aliskiren in diabetic patients

Side Effects

• Common side effects
• Adverse events
• Elevations of liver enzymes
• Gastric irritation
• Photosensitivity

Pregnancy & Lactation

• Pregnancy Category D
• Adverse effects on fetal renal function
• Potential neonatal adverse effects
• Excretion in human milk
• Thiazides in human milk

Precautions & Warnings

• Medical history considerations
• Impact on blood sugar levels
• Effect on body potassium levels
• Dizziness precautions
• Dehydration prevention

Use in Special Populations

• Pediatric use considerations
• Geriatric dose selection
• Use in patients with hepatic impairment
• Use in patients with renal impairment
• Consideration for dose adjustment in renal impairment

Overdose Effects

• Manifestations of overdosage
• Hypertension effects
• Dehydration effects
• Tachycardia effects
• Hypokalemia effects

Therapeutic Class

• Combined antihypertensive preparations

Storage Conditions

• Keep out of reach of children
• Storage in cool and dry place
• Protection from light

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