Macflox 400 mg (Tablet)

Indications

• Acute bacterial sinusitis
• Acute exacerbation of chronic bronchitis
• Community acquired pneumonia
• Uncomplicated skin and skin structure infections
• Complicated skin and skin structure infections
• Complicated intra-abdominal infections
• Pelvic inflammatory disease

Pharmacology

• 4th generation synthetic broad-spectrum
• Fluoroquinolone class of antibacterial drug
• Activity against gram-positive, gram-negative, anaerobic and atypical bacteria
• Inhibits topoisomerase II and IV

Dosage & Administration

• 400 mg once daily for different durations depending on the condition

Interaction

• Decreased absorption when administered with antacids, sucralfate, or multivitamins
• Enhanced risk of convulsions with NSAIDs
• Enhanced risk of bleeding with warfarin

Contraindications

• Hypersensitivity to Moxifloxacin or other quinolones

Side Effects

• Nausea
• Vomiting
• Diarrhea
• Headache
• Dizziness

Pregnancy & Lactation

• Not recommended during pregnancy and lactation
• US FDA pregnancy category C

Precautions & Warnings

• Increased risk of tendinitis and tendon rupture
• Discontinue if pain or inflammation in a tendon occurs
• Not to be used in patients with known prolongation of the QT interval
• Not to be used in patients with uncorrected hypokalemia
• Not to be used in patients receiving Class IA or Class III antiarrhythmic agents

Use in Special Populations

• No dose adjustment necessary for renal or hepatic impaired patients
• Safety and effectiveness not established in pediatric patients and adolescents under 18 years of age

Therapeutic Class

• 4-Quinolone preparations

Storage Conditions

• Keep in a dry place
• Keep away from light and heat
• Keep out of the reach of children

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