Emetus 4 mg/5 ml (Oral Solution)

50 ml bottle: ৳ 50.00

Medicine Details

Category Details
Generic Ondansetron
Company Osl pharma limited
Also available as
Emetus 4 mg tablet Emetus 8 mg tablet Emetus 8 mg injection

Indications

  • Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
  • Prevention and treatment of post-operative nausea and vomiting
  • Prevention of radiotherapy-induced nausea and vomiting

Description

  • Type: Oral Soluble Film
  • Application: Applied on top of the tongue
  • Dissolution Time: Within 20 seconds
  • Active Ingredient: Emetus base
  • Molecular Weight: 293.3
  • Formula: C18H19N3O

Pharmacology

  • Mode of Action: 5HT3 receptor-antagonist
  • Blockage of Vagal Afferents: Prevents vomiting reflex
  • Central Mechanism: Antagonism of 5HT3 receptors in the central nervous system
  • Effect on Chemotherapy-induced Nausea and Vomiting: Antagonism of 5HT3 receptors in both peripheral and central nervous system

Dosage

  • Dosage Form:
    • Tablet
    • Orodispersible Tablet
    • Injection
  • Dosage Recommendations: Dependent on age, weight, and type of treatment

Administration

  • Steps:
    • Tear the pouch carefully along with the edge tear mark
    • Put the film on top of the tongue
    • Do not chew or swallow the film whole
    • Swallow after the film dissolves
    • Wash hands after administration

Interaction

Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes

Contraindications

  • Hypersensitivity to the drug or any of its components
  • Concomitant use of apomorphine

Side Effects

  • Common Adverse Events:
    • Headache
    • Constipation
    • Diarrhea
  • Frequency: Majority mild or moderate in nature
  • Chemotherapy-induced Nausea and Vomiting: Approximately 1% rash occurrence

Pregnancy & Lactation

  • Carcinogenic Effects: Not observed in animal studies
  • Excretion in Breast Milk: Caution advised when administered to nursing women

Precautions & Warnings

  • Hypersensitivity Reactions: Reported in patients with hypersensitivity to other 5-HT3 receptor antagonists
  • Gastrointestinal Stimulation: Not a peristalsis-stimulating drug

Use in Special Populations

  • Renal Function: Dosage recommendation same as general population
  • Hepatic Function: Recommendation for severe hepatic impairment
  • Pediatric Patients:
    • Limited information for patients 4 years of age or younger
    • No dosage adjustment needed for patients over the age of 65

Therapeutic Class

Anti-emetic drugs

Storage Conditions

Store at temperature not exceeding 30°C in a dry place, protect from light and moisture

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