Nuvifol 5 mg (Tablet)
Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Folinic acid |
| Company | Nuvista pharma ltd |
Indications
- Neutralising the immediate toxic effects of folic acid antagonists, e.g. methotrexate
- Calcium folinate rescue- a treatment technique using calcium folinate in conjunction with folic acid antagonists, e.g. methotrexate, to minimise systemic toxicity
- The treatment of megaloblastic anaemias due to sprue, nutritional deficiency, pregnancy, infancy, liver disease and malabsorption syndrome
Composition
- Calcium Folinate Hydrate BP 6.249 mg equivalent to Folinic Acid 5 mg
- Calcium Folinate Hydrate BP 18.746 mg equivalent to Folinic Acid 15 mg
Pharmacology
- Metabolite and active form of folic acid
- Cofactor for 1-carbon transfer reactions
- Impairment of thymidylate synthesis
- Potent antidote for hematopoietic and reticuloendothelial toxic effects of folic acid antagonists
Dosage & Administration
- Commencement of calcium folinate rescue within 24 hours of methotrexate administration
- Varying dosage regimens depending on the dose of methotrexate administered
- Recommended dose of Folinic Acid to counteract hematologic toxicity
Interaction
- Counteracting the antiepileptic effect of phenobarbitone, phenytoin and primidone
- Increase in seizures frequency with concurrent administration of calcium folinate with fluoropyrimidine
Contraindications
- Known hypersensitivity to calcium folinate or any other components of this product
- Pernicious anemia or other megaloblastic anemia where vitamin B12 is deficient
- Rare hereditary problems of galactose intolerance, the lapp lactase deficiency or glucose-galactose malabsorption
Side Effects
- Mucositis
- Stomatitis
- Leukopenia
- Diarrhea
Pregnancy & Lactation
- Use in pregnant women only if the potential benefit justifies the potential risk to the fetus
- Unknown excretion in human milk
Precautions & Warnings
- Use with methotrexate or 5-FU under the direct supervision of a clinician experienced in the use of cancer chemotherapeutic agents
- Avoid giving simultaneously with folic acid antagonists, e.g. methotrexate, to abort clinical toxicity
- Measures for prompt excretion of methotrexate in Calcium Folinate Rescue Therapy
Overdose Effects
- No reported sequelae in patients who have received significantly more calcium folinate than the recommended dosage
- Excessive amounts may nullify the chemotherapeutic effect of folic acid antagonists
- No specific antidote to calcium folinate overdose
Therapeutic Class
Supportive Care Therapy
Storage Conditions
Do not store above 30°C. Keep away from light and out of the reach of children