Clarinaaf 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Naafco pharma ltd |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Prevention of translocation to the donor site
- Activity against most Gram-positive bacteria
- Activity against Chlamydia and some Gram-negative bacteria
- Better acid-stability compared to Erythromycin
- Twice the activity against H. influenzae compared to Erythromycin
- Resistance of most species of Gram-negative bacteria
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease
- Combination dosing regimens for H. pylori infection
- Recommended daily dosage for children
- Special considerations for renal and hepatic impairment
Interaction
- Contraindications with specific medication classes
- Contraindicated when co-administered with HMG-CoA reductase inhibitors
- Contraindicated with gastroprokinetic agents
- Contraindicated with ergot alkaloids
- Contraindicated with antipsychotics
- Contraindicated with anti-gout agents
- Drug interactions with antiarrhythmics
Contraindications
- Contraindicated in patients with known hypersensitivity
- Contraindicated in patients with a history of cholestatic jaundice
- Contraindicated in patients with hepatic dysfunction associated with prior use
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient CNS side effects
Pregnancy & Lactation
- Use in neonates and children with appropriate doses
- Avoidance of breast milk from mothers receiving Clarithromycin
- Not recommended in pregnant patients
Precautions & Warnings
- Discontinuation upon severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Discontinuation upon signs and symptoms of hepatitis
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients 6 months and older
- Prevention of disseminated Mycobacterium avium complex (MAC) disease in pediatric patients 20 months and older with advanced HIV infection
- Lack of study of safety in MAC patients under 20 months
- No established safety and effectiveness in pediatric patients under 6 months
Overdose Effects
- Expected gastrointestinal symptoms with large amounts
- Case study of altered mental status, paranoid behavior, hypokalemia, and hypoxemia with 8 grams ingestion
- Adverse reactions treatment with prompt drug elimination and supportive measures
- Insensitivity of Clarithromycin serum levels to haemodialysis or peritoneal dialysis
Therapeutic Class
- Macrolides
Storage Conditions
- Storage in cool and dry place
- Protection from light and moisture
- Duration of reconstituted suspension use at room temperature and refrigerated
- Precaution to keep out of reach of children