Esitanaaf 10 mg (Tablet)

Unit Price: ৳ 11.00 (3 x 10: ৳ 330.00)
Strip Price: ৳ 110.00

Medicine Details

Category Details
Generic Escitalopram oxalate
Company Naafco pharma ltd
Also available as

Indications

  • Treatment of major depressive episodes
  • Treatment of panic disorder with or without agoraphobia
  • Treatment of social anxiety disorder (social phobia)
  • Treatment of generalised anxiety disorder
  • Treatment of obsessive-compulsive disorder

Pharmacology

  • Orally administered selective serotonin reuptake inhibitor (SSRI)
  • Pure S-enantiomer of the racemic bicyclic phthalate derivative citalopram
  • At least 100 fold more potent than the R-enantiomer with respect to inhibition of 5-HT reuptake
  • No or very low affinity for serotonergic or other receptors including alpha- and beta-adrenergic Dopamine, Histamine, Muscarinic and benzodiazepine receptors

Dosage

  • Safety of daily doses above 20 mg has not been demonstrated
  • Administered as a single daily dose
  • Usual dosage is 10 mg once daily for major depressive episodes
  • An initial dose of 5 mg is recommended for panic disorder with or without agoraphobia
  • Usual dosage is 10 mg once daily for social anxiety disorder
  • Initial dosage is 10 mg once daily for generalised anxiety disorder
  • Initial dosage is 10 mg once daily for obsessive-compulsive disorder

Administration

  • Generally administered once daily, morning or evening with or without food

Interaction

  • SSRI or related antidepressants should not be started until 2 weeks after stopping an MAOI
  • An MAOI should not be started until at least a week after an SSRI or related antidepressant has been stopped (2 weeks in the case of paroxetine and sertraline, at least 5 weeks in the case of fluoxetine)

Contraindications

  • Contraindicated in patients with known hypersensitivity to Escitalopram or Citalopram or any of the inactive ingredients of the drug product
  • Concomitant use of escitalopram in patients taking monoamine oxidase/pimozide is contraindicated

Side Effects

  • Less sedating and have fewer antimuscarinic and cardiotoxic effects than tricyclic antidepressants
  • Include gastrointestinal effects, anorexia with weight loss or increased appetite and weight gain, hypersensitivity reactions, dry mouth, nervousness, anxiety, headache, insomnia, tremor, dizziness, asthenia, hallucinations, drowsiness, convulsions, galactorrhoea, sexual dysfunction, urinary retention, sweating, hypomania or mania, movement disorders and dyskinesias, visual disturbances

Pregnancy & Lactation

  • When treating a pregnant woman with Escitalopram during the third trimester, the physician should carefully consider the potential risks and benefits of treatment
  • Excreted in human breast milk
  • Decision whether to continue or discontinue nursing or Escitalopram therapy should take into account the risk of citalopram exposure for the infant and the benefits Escitalopram treatment for the mother

Precautions & Warnings

  • Should be used with caution in patients with epilepsy, concurrent electroconvulsive therapy, history of mania, cardiac disease, diabetes mellitus, angle-closure glaucoma, concomitant use of drugs that increase risk of bleeding, history of bleeding disorders, hepatic and renal impairment

Use in Special Populations

  • Elderly patients (>65 years of age): Initial dosage is 5 mg once daily
  • Children and adolescents (<18 years): Esitanaaf should not be used in the treatment of children and adolescents under the age of 18 years
  • Reduced renal function: Dosage adjustment is not necessary in patients with mild or moderate renal impairment
  • Reduced hepatic function: An initial dose of 5 mg daily for the first two weeks of treatment is recommended in patients with mild or moderate hepatic impairment
  • Poor metabolizers of CYP2C19: An initial dose of 5 mg daily during the first two weeks of treatment is recommended
  • When stopping treatment with escitalopram the dose should be gradually reduced over a period of at least one to two weeks in order to reduce the risk of discontinuation symptoms

Overdose Effects

  • Symptoms include those related to the central nervous system, gastrointestinal system, and cardiovascular system, as well as electrolyte/fluid balance conditions
  • There is no specific antidote
  • Establish and maintain an airway, ensure adequate oxygenation and respiratory function
  • Gastric lavage and the use of activated charcoal should be considered
  • ECG monitoring is advised in case of overdose

Therapeutic Class

  • SSRIs & related anti-depressant drugs

Storage Conditions

  • Store below 30°C temperature and protect from light & moisture
  • Keep the medicine out of the reach of children

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