Vomistop 4 mg/5 ml (Oral Solution)
50 ml bottle: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Naafco pharma ltd |
Indications
- Prevention of nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Dosage
- Different dosages for adults, pediatric patients, and based on the type of nausea and vomiting
- Dosage varies for highly emetogenic and moderately emetogenic cancer chemotherapy
- Specific dosages for pediatric patients
Mode of Action
- Potent and highly selective 5HT3 receptor-antagonist
- Blocks the initiation of vomiting reflex
- Antagonism of 5HT3 receptors in both peripheral and central nervous systems
Administration
- Oral soluble film designed to be applied on top of the tongue
- Dissolves within 20 seconds and swallowed with saliva
- Does not require water for dissolution or swallowing
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change clearance and half-life
- No dosage adjustment recommended based on available data
Contraindications
- Hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events include headache, constipation, and diarrhea
- Rare cases of anaphylaxis, brochospasm, tachycardia
- No evidence of extrapyramidal reactions
Pregnancy & Lactation
- No evidence of impaired fertility or harm to the fetus in animal studies
- Caution advised when administered to nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to selective 5-HT3 receptor antagonists
- Should not be used instead of nasogastric suction
- May mask a progressive ileus and/or gastric distension
Use in Special Populations
- Same dosage recommendation for patients with impaired renal function
- Recommended single maximal daily dose in severe hepatic impairment
- Little information available about dosage in pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light and moisture