Zinaclav 250 mg+62.5 mg (Tablet)

Unit Price: ৳ 35.00 (2 x 7: ৳ 490.00)
Strip Price: ৳ 245.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Dbl pharmaceuticals ltd
Also available as
Zinaclav 500 mg tablet

Title

Zinaclav 250 mg Tablet

Categories

  • Antibiotics
  • Medication
  • Healthcare

Description

Zinaclav 250 mg Tablet is indicated for the treatment of infections caused by sensitive bacteria. It contains Cefuroxime, a bactericidal second generation cephalosporin antibiotic, and Clavulanic acid, a beta-lactamase inhibitor. It is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains.

Dosage

  • Adolescents and Adults (13 years and older):
    • Pharyngitis/Tonsillitis: 250 mg b.i.d. for 5-10 days
    • Acute Bacterial Maxillary Sinusitis: 250 mg b.i.d. for 10 days
    • Acute Bacterial Exacerbation of Chronic Bronchitis: 250-500 mg b.i.d. for 10 days
    • Uncomplicated Skin and Skin Structure Infections: 250-500 mg b.i.d. for 10 days
    • Uncomplicated Urinary Tract Infections: 250 mg b.i.d. for 7-10 days
    • Uncomplicated Gonorrhoea: 1000 mg b.i.d. Single dose
  • Paediatric Patients (3 months to 12 years):
    • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d for 5-10 days
    • Acute Otitis Media: 30 mg/kg/day b.i.d for 10 days
    • Acute Bacterial Maxillary Sinusitis: 30 mg/kg/day b.i.d for 10 days
    • Impetigo: 30 mg/kg/day b.i.d for 10 days
  • Instructions: Cefuroxime-Clavulanic Acid tablet may be taken without regard of food.

Indications

  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by various bacteria
  • Acute Bacterial Exacerbation of Chronic Bronchitis
  • Uncomplicated Skin and Skin Structure Infections
  • Uncomplicated Urinary Tract Infections
  • Uncomplicated Gonorrhoea
  • Community-Acquired Pneumonia
  • MDR Typhoid Fever
  • Early Lyme Disease
  • Septicemia
  • Meningitis
  • Switch Therapy (Injectable to Oral)

Pharmacology

  • Mechanism of Action: Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process. Clavulanic acid provides protection of Cefuroxime from degradation by beta-lactamase enzymes.

Interaction

Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the serum concentration. Drug that reduces gastric acidity may result in lower bioavailability of Cefuroxime.

Contraindications

  • Known allergy to cephalosporin
  • Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Prolonged administration may result in overgrowth of nonsusceptible microorganisms
  • Rarely: renal dysfunction, anaphylaxis, angioedema, pruritis, rash

Pregnancy & Lactation

  • Safe for use in later pregnancy
  • Excreted into breast milk in small quantities

Precautions & Warnings

Cefuroxime should be given with care to patients receiving concurrent treatment with potent diuretics & patients with a history of colitis.

Therapeutic Class

Second Generation Cephalosporins

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.

Commonly Asked Questions

  • What is Zinaclav 250 mg Tablet?: Cefuroxime is the cephalosporin antibiotic and Clavulanic acid is a beta-lactamase inhibitor. Zinaclav 250 mg Tablet is indicated for the treatment of infections caused by sensitive bacteria.
  • What is Zinaclav 250 mg Tablet used for?: Zinaclav 250 mg Tablet is used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever.
  • How long does it take for Zinaclav 250 mg Tablet to take effect?: Zinaclav 250 mg Tablet starts working within 2-3 hours after taking it.
  • How long do the effects of this medicine last?: The effect of Zinaclav 250 mg Tablet lasts for an average duration of 4-8 hours.
  • Zinaclav 250 mg Tablet it safe to consume alcohol while taking this medicine?: Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is Zinaclav 250 mg Tablet a habit forming medicine?: No habit-forming tendencies were reported for Zinaclav 250 mg Tablet.
  • Can this medicine be taken during pregnancy?: Zinaclav 250 mg Tablet is safe to use in pregnancy to treat bacterial infections. However, it is recommended to use this medicine only after consulting your doctor.
  • Can Zinaclav 250 mg Tablet be taken while breastfeeding?: Zinaclav 250 mg Tablet is safe to use during breastfeeding. It enters into breast milk at low levels.
  • Quick Tips:
    • Prescribed for bacterial infections, even if they have developed resistance
    • Finish the full course of treatment even if you feel better
    • Take it with food to avoid an upset stomach
    • Stop taking if an itchy rash, swelling, or breathing difficulties occur
    • Consult your doctor before taking any antibiotic

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