Zinaclav 500 mg+125 mg (Tablet)

Unit Price: ৳ 65.00 (2 x 7: ৳ 910.00)
Strip Price: ৳ 455.00

Medicine Details

Category Details
Generic Cefuroxime axetil clavulanic acid
Company Dbl pharmaceuticals ltd
Also available as
Zinaclav 250 mg tablet

Indications

  • Treatment of infections caused by sensitive bacteria
  • Pharyngitis/Tonsillitis caused by Streptococcus pyogenes
  • Acute Bacterial Otitis Media caused by Streptococcus pneumoniae
  • Lower respiratory tract infections including pneumoniae
  • Uncomplicated skin and skin-structure infections
  • Uncomplicated urinary tract infections
  • Bone and Joint Infections
  • Uncomplicated Gonorrhoea
  • Early Lyme Disease (erythema migrans)
  • Septicemia
  • Meningitis
  • Switch therapy (Injectable to oral)

Pharmacology

  • Bactericidal second generation cephalosporin antibiotic
  • Active against a wide range of Gram-positive and Gram-negative susceptible organisms
  • Inhibits bacterial cell wall synthesis by interfering with the transpeptidation process
  • Beta lactamase inhibitor produced by Streptomyces clavuligerus
  • Protection of Cefuroxime from degradation by beta lactamase enzymes

Dosage & Administration

  • Dosage for Adolescents and adults (13 years and older)
  • Dosage for Paediatric Patients (3 months to 12 years)
  • Tablet may be taken without regard of food

Interaction

  • Concomitant administration of probenecid with Cefuroxime-Clavulanic Acid increases the area under the serum concentration versus time curve by 50%
  • Drug that reduces gastric acidity may result in a lower bioavailability of Cefuroxime

Contraindications

  • Contraindicated in patients with known allergy to cephalosporin
  • Contraindicated in patients with Pseudomembranous Colitis

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort or pain
  • Overgrowth of nonsusceptible microorganisms
  • Renal dysfunction
  • Anaphylaxis
  • Angioedema
  • Pruritis
  • Rash
  • Serum sickness like urticaria

Pregnancy & Lactation

  • Should be avoided in the first trimester if possible
  • Can be safely used in later pregnancy to treat urinary and other infections
  • Excreted into the breast milk in small quantities

Precautions & Warnings

  • Given with care to patients receiving concurrent treatment with potent diuretics
  • Given with care to patients with a history of colitis

Therapeutic Class

  • Second generation Cephalosporins

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light and moisture
  • Keep out of the reach of children

Common Questions about Zinaclav 500 mg Tablet

  • Cefuroxime-Clavulanic Acid is the cephalosporin antibiotic and beta-lactamase inhibitor
  • Used to treat pharyngitis, tonsillitis, sinusitis, bronchitis, SSTI, UTI, gonorrhoea, pneumonia, typhoid fever
  • Starts working within 2-3 hours after taking it
  • Effects last for an average duration of 4-8 hours
  • Interaction with alcohol is unknown
  • Not a habit-forming medicine
  • Safe to use during pregnancy to treat bacterial infections
  • Safe to use during breastfeeding
  • Prescribed to treat bacterial infections even if they have developed resistance
  • Do not skip any doses and finish the full course of treatment even if you feel better
  • Taking probiotics may help with diarrhea
  • Stop taking and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties
  • Do not use leftover medicine for treating any infection in the future

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