Esuvast 5 mg (Tablet)

ProductTitle

• Esuvast 5 mg Tablet

Categories

• Medicine
• Health & Wellness
• Cholesterol Management

Description

• Esuvast is indicated for primary hyperlipidemia, mixed dyslipidemia, hypertriglyceredemia, primary dysbetalipoproteinemia, homozygous familial hypercholesterolemia, slowing the progression of atherosclerosis, and risk reduction of Myocardial Infarction (MI), stroke and arterial revascularization procedures in patients without clinically evident CHD, but with multiple risk factors.

DosageAndAdministration

• Usual dose range is 5-20 mg/day; 40 mg once daily for very high cholesterol and high risk of MI or stroke; recommended starting dose for homozygous familial hypercholesterolemia is 20 mg once daily; for Asian patients, consider initiation with 5 mg once daily; in specific drug combinations, the dose should be limited to ensure safety.

Pharmacology

• Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, enhancing hepatic LDL receptor numbers and inhibiting hepatic synthesis of VLDL and LDL particles.

Interaction

• Remarkable drug interactions include effects with Cyclosporine, Gemfibrosil, Lopinavir/Ritonavir or atazanavir/ritonavir, Coumarin anticoagulants, and concomitant lipid-lowering therapies.

Contraindications

• Contraindicated in cases of known hypersensitivity to product components, liver disease, pregnancy, and nursing mothers.

SideEffects

• Frequent adverse events thought to be related to Esuvast include headache, myalgia, constipation, asthenia, abdominal pain, and nausea.

PregnancyAndLactation

• Should be administered to women of childbearing age only when pregnancy is highly unlikely; therapy should be discontinued immediately if pregnancy occurs.

PrecautionsAndWarnings

• Should be prescribed with caution in patients with predisposing factors for myopathy; therapy should be discontinued in case of markedly elevated creatinine kinase levels or myopathy.

OverdoseEffects

• No specific treatment in the event of overdose; patient should be treated symptomatically and supportive measures instituted as required; hemodialysis does not significantly enhance clearance of Esuvast.

TherapeuticClass

• Other Anti-anginal & Anti-ischaemic drugs, Statins

StorageConditions

• Keep below 30°C temperature, protected from light & moisture; keep out of the reach of children.

ChemicalStructure

• Molecular Formula: C22H28FN3O6S
• Chemical Structure: Image available

Indications

• Primary Hyperlipidemia
• Mixed Dyslipidemia
• Hypertriglyceredemia
• Primary Dysbetalipoproteinemia
• Homozygous Familial Hypercholesterolemia
• Slowing the progression of atherosclerosis
• Risk reduction of Myocardial Infarction (MI)
• Stroke and Arterial Revascularization Procedures

UsabilityFeatures

• Lowers cholesterol levels
• Reduces triglycerides
• Inhibits hepatic synthesis of VLDL and LDL particles
• Enhances hepatic LDL receptor numbers

DosageRange

• 5-20 mg/day

MaximumRecommendedDose

• 20 mg/day

AsianPatientsInitiationDose

• 5 mg/day

SpecificDrugCombinationsDoseLimitations

• Cyclosporine: 5 mg/day
• Gemfibrosil: 10 mg/day
• Lopinavir/Ritonavir or Atazanavir/Ritonavir: 10 mg/day

DrugInteractions

• Cyclosporine
• Gemfibrosil
• Lopinavir/Ritonavir
• Atazanavir/Ritonavir
• Coumarin anticoagulants
• Concomitant lipid-lowering therapies

AdverseEvents

• Headache
• Myalgia
• Constipation
• Asthenia
• Abdominal pain
• Nausea

PregnancyAndLactationPrecautions

• Administer to women of childbearing age only when pregnancy is highly unlikely
• Discontinue immediately if pregnancy occurs

LiverEnzymeTestsFrequency

• Before initiation and at 12 weeks following initiation and any dose elevation

DrugStorageTemperature

• Below 30°C

ChemicalStructureMolecularFormula

C22H28FN3O6S

IndicationAges

• Pediatric patients 10 to 17 years of age

IndicationUsage

• As an adjunct to diet to reduce elevated total-C, LDL-C, ApoB, non HDL-C and TG levels and to increase HDL-C

LiverDiseaseContraindication

Contraindicated in cases of liver disease

PregnancyContraindication

• Contraindicated in pregnant women and women who may become pregnant

NursingMothersContraindication

Contraindicated in nursing mothers

MusclePainPrecaution

Prescribed with caution in patients with predisposing factors for myopathy

FrequentAdverseEvents

• Headache
• Myalgia
• Constipation
• Asthenia
• Abdominal pain
• Nausea

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