Indarol Plus 110 mcg+50 mcg (Inhalation Capsule)

Unit Price: ৳ 70.00 (3 x 10: ৳ 2,100.00)
Strip Price: ৳ 700.00

Medicine Details

Category Details
Generic Indacaterol glycopyrronium
Company Healthcare pharmaceuticals ltd
Also available as
Indarol plus 275 mcg inhalation capsule

Indications

  • Long-term once-daily maintenance bronchodilator treatment
  • Airflow obstruction
  • COPD (Chronic Obstructive Pulmonary Disease)
  • Chronic bronchitis
  • Emphysema

Composition

  • Indacaterol 110 mcg as Indacaterol Maleate INN (Micronized)
  • Glycopyrronium 50 mcg as Glycopyrronium Bromide BP (Micronized)

Pharmacology

  • Delivery of a combination of Glycopyrronium and Indacaterol by oral inhalation
  • Stimulation of intracellular adenyl cyclase
  • Relaxation of bronchial smooth muscle
  • Inhibition of release of mediators of immediate hypersensitivity from cells

Dosage & Administration

  • For oral inhalation only
  • Maintenance treatment of COPD: 1 inhalation once daily
  • Limitations of use: Not indicated for relief of acute bronchospasm or for the treatment of asthma
  • Geriatric use
  • Use in Children & Adolescents: Not indicated
  • Renal impairment use
  • Hepatic impairment use

Interaction

  • No specific interaction studies conducted for Glycopyrronium and Indacaterol combination
  • Concomitant use with β-adrenergic blockers, anticholinergics or sympathomimetic agents not recommended
  • Caution required with concomitant use of hypokalemic treatment

Contraindications

  • Hypersensitivity to Glycopyrronium or Indacaterol
  • Severe hypersensitivity to milk proteins
  • LABA treatment contraindicated in patients with asthma without use of a long-term asthma control medication

Side Effects

  • Cardiovascular effects
  • Ocular disorders
  • Urinary retention
  • Gastrointestinal disorders
  • Dry mouth
  • Cough
  • β2-agonist immediate hypersensitivity reactions
  • Hypokalemia
  • Hyperglycemia
  • Headache
  • Nervousness
  • Insomnia
  • Muscle spasms
  • Fatigue
  • Malaise
  • Tremor
  • Oropharyngeal pain

Pregnancy & Lactation

  • Pregnancy category C
  • Use during pregnancy should justify potential risk to the fetus
  • Consideration of use during breastfeeding if expected benefit to the woman is greater than any possible risk to the infant

Precautions & Warnings

  • Increased risk of serious asthma-related events with LABA monotherapy
  • Not to be initiated in acutely deteriorating COPD or asthma
  • Caution in patients with cardiovascular disorders
  • Caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, and ketoacidosis
  • Risk of paradoxical bronchospasm
  • Worsening of narrow-angle glaucoma
  • Worsening of urinary retention
  • Alert to hypokalemia and hyperglycemia

Overdose Effects

  • Clinically relevant overdosing effects
  • Exaggerated effects typical of β2-adrenergic stimulants
  • Anticholinergic effects
  • Hospitalization in serious cases

Therapeutic Class

  • Combined bronchodilators

Storage Conditions

  • Avoid direct sunlight or heat
  • Store in a cool & dry place
  • Keep away from eyes
  • Keep out of reach of children

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