Olic 5 mg (Tablet)
Unit Price: ৳ 27.00 (2 x 10: ৳ 540.00)
Strip Price: ৳ 270.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Obeticholic acid |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Treatment of primary biliary cholangitis in adult patients
- Combination therapy with ursodeoxycholic acid (UDCA)
- Monotherapy in patients unable to tolerate UDCA
- For patients with or without cirrhosis
- For patients with compensated cirrhosis without evidence of portal hypertension
Pharmacology
- Mechanism of action as FXR agonist
- Regulation of bile acid pathways
- Bile acid homeostasis
- Reduction of hepatocyte concentrations of bile acids
Dosage & Administration
- Dosage regimen for PBC patients
- Monitoring for biochemical response and tolerability
- Management of patients with intolerable pruritus
Interaction
- Interaction with bile acid binding resins
- Interaction with warfarin
- Effect on CYP1A2 substrates
- Avoidance of concomitant use with BSEP inhibitors
Contraindications
- Decompensated cirrhosis
- Compensated cirrhosis with evidence of portal hypertension
- Complete biliary obstruction
Side Effects
- Pruritus
- Fatigue
- Stomach pain and discomfort
- Rash
- Joint pain
- Oropharyngeal pain
- Dizziness
- Constipation
- Abnormal thyroid function
- Eczema
Pregnancy & Lactation
- Insufficient data on use during pregnancy
- No information on presence in human milk
- Consideration of benefits of breastfeeding vs. maternal need
Precautions & Warnings
- Hepatic decompensation and failure in PBC patients with cirrhosis
- Severe pruritus
- Reduction in HDL-C levels
- Monitor changes in serum lipid levels
- Consideration of pediatric use and geriatric sensitivity
Use in Special Populations
- Lack of established safety and effectiveness in pediatric patients
- Evaluation of use in geriatric individuals
- Risk of hepatic decompensation and failure in patients with hepatic impairment
Overdose Effects
- Dose-dependent increase in hepatic adverse reactions
- Supportive care in case of overdosage
Therapeutic Class
- Farnesoid X Receptor Agonists
Storage Conditions
- Storage below 30°C
- Dry place and protection from light
- Keep out of children's reach