Clotrizen 1% (Cream)
10 gm tube: ৳ 35.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clotrimazole topical |
| Company | Beacon pharmaceuticals plc |
Indications
- All dermatomycoses due to dermatophytes (e.g.Trichophyton species)
- All dermatomycoses due to yeasts (Candida species)
- Dermatomycoses due to moulds and other fungi
- Skin diseases showing superinfections with these fungi
- Interdigital mycoses (e.g. athlete's foot)
- Paronychias (associated with nail mycoses)
- Mycoses in skin folds
- Candida vulvitis
- Candida balanitis
- Pityriasis versicolor
- Erythrasma
Description
- Broad-spectrum antifungal agent
- Treats dermal infections caused by various species of pathogenic dermatophytes, yeasts, moulds, and bacteroids
- Active against certain gram-positive bacteria especially Staphylococci and Tricomonas
- Alters permeability of fungal cell walls by interfering with cell wall lipids
- Inhibition of ergosterol synthesis
- Mechanism of membrane damage unrelated to sterol synthesis
Pharmacology
- Damages the permeability barrier in the cell membrane of fungi
- Inhibition of ergosterol biosynthesis
- Inhibits lanosterol 14-demethylase (CYP51)
- Depletion of intracellular calcium
- Blocking of calcium‐dependent potassium channels and voltage‐dependent calcium channels
Dosage & Administration
- Thinly applied 2-3 times daily to the infected sites and rubbed in
- Small amount of cream usually sufficient for an area about the size of the palm
- Duration of treatment varies based on the extent and localization of the disease
- Recommended duration of treatment for specific infections
Interaction
- No information available
Contraindications
- Hypersensitivity to Clotrimazole
Side Effects
- Well tolerated when applied topically
- No systemic effects observed with external application
- Local irritation or burning sensation may occur in very few cases
Pregnancy & Lactation
- Recommended for use in pregnancy only when considered necessary by the physician
Therapeutic Class
- Drugs for subcutaneous and mycoses
- Topical Antifungal preparations
Storage Conditions
- Keep below 25°C temperature
- Away from light & moisture
- Keep out of the reach of children