Emfogen M 12.5 mg+1000 mg (Tablet)
Unit Price: ৳ 28.00 (2 x 6: ৳ 336.00)
Strip Price: ৳ 168.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Empagliflozin metformin hydrochloride |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of adults with type 2 diabetes mellitus
- Adjunct to diet and exercise
- Patients insufficiently controlled on Metformin alone
- Combination with other medicinal products for diabetes
- Patients already being treated with Empagliflozin and Metformin separately
Pharmacology
- Empagliflozin is an inhibitor of Sodium-Glucose Co-Transporter 2 (SGLT2)
- Metformin Hydrochloride is a biguanide type oral antihyperglycemic drug
- Reduces renal reabsorption of glucose
- Lowers the renal threshold for glucose
- Increases urinary glucose excretion
- Lowers basal and postprandial plasma glucose
- Does not produce hypoglycemia
Dosage & Administration
- Dosage individualized based on effectiveness and tolerability
- Take twice daily with meals
- Dose escalation should be gradual
- Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg
- Maximum recommended daily dose of Empagliflozin is 25 mg
- Extended-release formulations available
- Adjust dosing based on effectiveness and tolerability
- Renal impaired patient assessment
Interaction
- Diuretics co-administration leads to increased urine volume
- Insulin or Insulin Secretagogues co-administration increases risk for hypoglycemia
- Monitoring glycemic control with urine glucose tests not recommended
- Drugs that Reduce Metformin Clearance may increase the accumulation of Metformin
- Carbonic Anhydrase Inhibitors may increase risk of lactic acidosis
- Alcohol can potentiate the effect of Metformin on lactate metabolism
Contraindications
- Hypersensitivity to Empagliflozin and Metformin
- Acute metabolic acidosis
- Diabetic pre-coma
- Severe renal failure
- Acute conditions altering renal function
- Diseases causing tissue hypoxia
- Hepatic impairment
- Acute alcohol intoxication
Side Effects
- Urinary tract infection
- Female genital mycotic infections
- Diarrhea
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
- Headache
- Hypoglycemia
- Gastrointestinal symptoms
- Vaginal moniliasis
- Vulvovaginitis
- Balanitis and other genital infection
- Thirst
- Taste disturbance
- Pruritus (generalised)
- Rash
- Increased urination
- Increased serum lipids
- Volume depletion
- Urticaria
- Dysuria
- Increased blood creatinine/Glomerular filtration rate
Pregnancy & Lactation
- Potential risk to fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Lactic Acidosis risk
- Hypotension risk
- Ketoacidosis risk
- Acute kidney injury & impairment in renal function precautions
- Urinary tract infection risks
- Hypoglycemia risk
- Vitamin B12 Deficiency monitoring
- Increased LDL-C monitoring
- Macrovascular Outcomes monitoring
Overdose Effects
- No toxicity at high doses of Empagliflozin
- Lactic acidosis in high Metformin doses
- Hypoglycemia not seen with high Metformin doses
- Lactic acidosis is a medical emergency
- Treatment should be initiated as appropriate
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Keep below 30°C temperature
- Protected from light & moisture
- Keep out of the reach of children