Co-Clav 500 mg+125 mg (Tablet)

Unit Price: ৳ 32.00 (5 x 4: ৳ 640.00)
Strip Price: ৳ 128.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Ad din pharmaceuticals ltd
Also available as
Co clav 125 mg suspension

Indications

  • Upper respiratory tract infections
  • Lower respiratory tract infections
  • Genito-urinary tract infections
  • Skin and soft tissue infections
  • Bone and joint infections

Composition

  • 375 mg tablet contains Amoxicillin 250 mg and Clavulanic Acid 125 mg
  • 625 mg tablet contains Amoxicillin 500 mg and Clavulanic Acid 125 mg
  • 1 gm tablet contains Amoxicillin 875 mg and Clavulanic Acid 125 mg
  • Powder for Suspension: Each 5 ml reconstituted suspension contains Amoxicillin 125 mg and Clavulanic Acid 31.25 mg
  • Powder for Suspension (Forte): Each 5 ml reconstituted suspension contains Amoxicillin 400 mg and Clavulanic Acid 57.5 mg
  • 1.2 gm Injection: Each vial contains Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm) and Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)

Pharmacology

  • Broad spectrum of bactericidal activity
  • Inactivation of a wide range of beta-lactamase enzymes

Dosage

  • Usual adult dose: one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours
  • Children 6-12 years: 2 teaspoonful every 8 hours
  • Children 1-6 years: 1 teaspoonful every 8 hours
  • IV Injection for adults: Usually, 1.2 gm every 8 hours

Administration

  • Oral dosage form can be taken without regard to meals
  • IV injection can be administered over 2 minutes or slow intravenous infusion over 30 minutes

Interaction

  • Prolongation of bleeding time and prothrombin time reported in some patients

Contraindications

  • History of Penicillin hypersensitivity
  • Previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice

Side Effects

  • Diarrhoea
  • Indigestion
  • Nausea
  • Vomiting
  • Hepatitis
  • Cholestatic jaundice
  • Urticarial and erythematous rashes
  • Angioedema
  • Anaphylaxis

Pregnancy & Lactation

  • Animal studies show no teratogenic effect
  • Trace quantities of Amoxicillin detected in breast milk

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction

Use in Special Populations

  • Dose adjustment in case of patients with renal impairment

Overdose Effects

  • Gastrointestinal symptoms
  • Disturbance of the fluid and electrolyte balances

Therapeutic Class

  • Broad spectrum penicillins

Reconstitution

  • IV injection can be reconstituted by dissolving the powder in 20 ml Water for Injection BP

Storage Conditions

  • Store below 25°C, protected from light and moisture

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