Lamo 50 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Opsonin pharma ltd |
| Also available as |
Title & Categories
- Lamo (Lamotrigine) - Antiepileptic Drug
- Medicine
- Phenyltriazine Antiepileptic
Indications
- Adjunctive therapy in patients aged 2 years and older for Partial-onset seizures
- Adjunctive therapy in patients aged 2 years and older for Primary generalized tonic-clonic seizures
- Adjunctive therapy in patients aged 2 years and older for Generalized seizures of Lennox-Gastaut syndrome
- Monotherapy in patients aged 16 years and older for Epilepsy
- Treatment for Bipolar disorder in patients aged 18 years and older
Description
Controls epileptic seizures by inhibiting voltage-sensitive sodium channels, stabilizes neuronal membranes and inhibits presynaptic excitatory neurotransmitter release
Mode of Action
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Modulates the release of presynaptic excitatory neurotransmitters
- Binds weakly to various receptors like serotonin 5-HT3, Adenosine A1/A2, dopamine D1/D2, GABA A/B, histamine H1, etc.
Dosage & Administration
- Escalation Regimen for Lamotrigine in Patients Older than 12 Years with Epilepsy
- Escalation Regimen for Lamotrigine in Patients Aged 2 to 12 Years with Epilepsy
- Escalation Regimen for Lamotrigine in Adults with Bipolar Disorder
- Initial Weight-Based Dosing Guide for Patients Aged 2 to 12 Years Taking Valproate with Epilepsy
Interaction
- Valproate increases Lamo concentrations by more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamo concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease Lamo concentrations by approximately 50%
- Protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir decrease Lamo exposure by approximately 50% and 32% respectively
Side Effects
- Dizziness
- Headache
- Diplopia
- Ataxia
- Nausea
- Blurred vision
- Somnolence
- Pharyngitis
- Rash
- Vomiting
- Diarrhea
- Infection
- Fever
- Abdominal pain
- Tremor
Pregnancy & Lactation
Pregnancy Category C. Lamo is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Precautions & Warnings
- Discontinue at the first sign of rash
- Monitor for blood dyscrasias
- Monitor for suicidal behavior and ideation
- Monitor for signs of aseptic meningitis
Use in Special Populations
- Lamo not demonstrated as safe and effective in very young pediatric patients aged 1 to 24 months for Epilepsy
- Lamo not established as safe and effective in pediatric patients aged 10 to 17 years for Bipolar Disorder
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
Primary anti-epileptic drugs
Storage Conditions
Keep out of reach of children, Store in a dry place, below 25°C temperature and protected from light