Lamo 25 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for Lennox-Gastaut syndrome seizures
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment of bipolar disorder in patients aged 18 years and older
Description
- Phenyltriazine antiepileptic
- Used to control epileptic seizures
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Inhibits presynaptic excitatory neurotransmitter release
Pharmacology
- Inhibition of voltage-sensitive sodium channels
- Modulation of release of excitatory neurotransmitters
- Binding properties to several receptors
- Inhibitory effect on serotonin 5-HT3 receptor
- Binding to multiple adrenergic, dopamine, GABA, histamine, and opioid receptors
- Inhibition of R-type calcium currents
Dosage & Administration
- Escalation regimen for patients older than 12 years with epilepsy
- Escalation regimen for patients aged 2 to 12 years with epilepsy
- Escalation regimen for adults with bipolar disorder
- Initial weight-based dosing guide for pediatric patients with epilepsy
- Usual maintenance doses for different patient groups
Interaction
- Increase in concentrations with valproate
- Decrease in concentrations with carbamazepine, phenytoin, phenobarbital, primidone, rifampin, and estrogen-containing oral contraceptives
- Decrease in exposure with protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir
Side Effects
- Adult side effects: dizziness, headache, diplopia, nausea, blurred vision
- Children side effects: vomiting, diarrhea, infection, fever, abdominal pain, tremor
Pregnancy & Lactation
- Pregnancy Category C
- Excretion in human milk
- Potential for serious adverse reactions in nursing infants
Precautions & Warnings
- Discontinue at first sign of rash
- Monitor for blood dyscrasias, suicidal behavior, ideation, and aseptic meningitis
Use in Special Populations
- Safety and effectiveness in pediatric patients for epilepsy and bipolar disorder
- Age-specific limitations for pediatric use
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
- Primary anti-epileptic drugs
Storage Conditions
- Keep out of reach of children
- Store below 25°C temperature
- Protected from light