Vasofex XR 5 mg (Tablet (Extended Release))
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Prazosin hydrochloride |
| Company | Biopharma limited |
| Also available as |
Indications
- Treatment of essential hypertension
- Treatment of secondary hypertension
- Treatment of left ventricular failure
- Treatment of Raynaud's phenomenon and disease
- Adjunct in the symptomatic treatment of benign prostatic hyperplasia
Pharmacology
- Decrease in total peripheral vascular resistance
- Selective inhibition of postsynaptic alpha-1-adrenoreceptors
- Lowering of blood pressure in supine and standing positions
- Reduction in left ventricular filling pressure
- Augmentation of cardiac output
- Improvement in urinary pressure profile in men with benign prostatic hyperplasia
- No adverse changes in serum lipid profile
Dosage & Administration
- Initial therapy with low starting dose
- Adjustment of dosage according to patient's response
- Twice or thrice daily maintenance dosage for hypertension
- Titration of dosage for left ventricular failure
- Recommended starting dosage for Raynaud's phenomenon and disease
- Usual maintenance dose for benign prostatic hyperplasia
- Initiation of therapy with 2.5 mg once daily for Prazosin XR Extended-Release Tablets
Interaction
- No adverse drug interaction observed with cardiac-glycosides, hypoglycemic agents, tranquilizers and sedatives, antiarrhythmic agents, and analgesic/anti-inflammatory agents
Contraindications
- Known sensitivity to quinazolines
Side Effects
- Dizziness
- Headache
- Drowsiness
- Weakness
- Palpitations
- Nausea
- Liver function abnormalities
- Pancreatitis
- Edema
- Orthostatic hypotension
- Dyspnea
- Faintness
- Tachycardia
- Nervousness
- Vertigo
- Hallucinations
- Depression
- Rash
- Pruritus
- Alopecia
- Urinary frequency
- Impotence
- Incontinence
- Priapism
- Blurred vision
- Epistaxis
- Tinnitus
- Dry mouth
- Nasal congestion
- Diaphoresis
- Fever
- Positive ANA liter
- Arthralgia
Pregnancy & Lactation
- No teratogenic effects seen in animal testing
- Use during pregnancy should be based on potential benefit justifying potential risk
- Excretion in small amounts in human milk
- Caution advised for nursing mothers
Precautions & Warnings
- Potential for postural hypotension
- Careful adjustment of diuretic dosage in left ventricular failure patients
- Careful monitoring of blood pressure for Raynaud's phenomenon and disease
- Careful monitoring of blood pressure for benign prostatic hyperplasia in elderly patients
- Not recommended for children under 12 years
- Not recommended in left ventricular failure due to mechanical obstruction
- No established data for efficacy in left ventricular failure due to recent myocardial infarction
Use in Special Populations
- Not recommended for children under 12 years
- Not recommended in left ventricular failure due to mechanical obstruction
- No data for efficacy in left ventricular failure due to recent myocardial infarction
Overdose Effects
- Profound drowsiness and depressed reflexes observed in accidental ingestion by a child
- No decrease in blood pressure noted
- Support of cardiovascular system of first importance
- Renal function monitoring and support as needed
- Not dialyzable because it is protein bound
Therapeutic Class
- Alpha adrenoceptor blocking drugs
Storage Conditions
- Store below 30°C
- Keep away from light and moisture
- Keep away from reach of children