Linadus M XR 5 mg+1000 mg (Tablet (Extended Release))

Indications

• Adjunct to diet and exercise
• Improves glycemic control
• Type 2 diabetes mellitus

Pharmacology

• Inhibitor of DPP-4 enzyme
• Increases active incretin hormones
• Stimulates insulin release
• Decreases glucagon secretion
• Oral antihyperglycemic drug
• Lowers plasma glucose
• Improves insulin sensitivity
• Decreases hepatic glucose production
• Decreases glucose absorption

Dosage & Administration

• Individualized dosage
• Maximum recommended dose
• Dose escalation
• Immediate release tablet
• Extended release tablet
• Gradual dose increase
• Recommended starting dose
• Dose adjustment
• Tablet intake instructions

Interaction

• Cationic drugs
• Renal tubular secretion
• Carbonic anhydrase inhibitors
• Metabolic acidosis risk
• P-glycoprotein and CYP3A4 inducers
• Drugs affecting glycemic control

Contraindications

• Renal impairment
• Metabolic acidosis
• Hypersensitivity

Side Effects

• Nasopharyngitis
• Diarrhea
• Hypoglycemia

Pregnancy & Lactation

• Caution during pregnancy
• Caution during lactation

Precautions & Warnings

• Lactic acidosis precautions
• Postmarketing reports of acute pancreatitis
• Discontinuation in suspected pancreatitis
• Radiologic study precautions
• Vitamin B12 monitoring
• Symptoms of lactic acidosis
• Precautions for alcohol consumption
• Precautions for other medicines
• Counseling for family members
• Travel precautions
• Emergency preparedness
• Hypoglycemia symptoms and treatment

Overdose Effects

• Supportive measures
• Removal of unabsorbed material
• Clinical monitoring
• Supportive treatment
• Dialyzable nature of Metformin Hydrochloride
• Dose-related adverse drug reactions
• Symptoms and effects of Metformin Hydrochloride overdose
• Hypoglycemia & lactic acidosis in Metformin Hydrochloride overdose cases

Therapeutic Class

• Oral hypoglycemic preparations

Storage Conditions

• Cool & dry storage
• Protection from light & moisture
• Keep out of reach of children

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