Bactolev 1.5% (Ophthalmic Solution)

Indications

• Treatment of bacterial conjunctivitis
• Treatment of bacterial corneal ulcer
• Treatment of blepharitis
• Treatment of hordeolum
• Treatment of perioperative conditions

Pharmacology

• Synthetic broad-spectrum antibiotic
• Bactericidal antibiotic
• Inhibition of bacterial topoisomerase IV and DNA gyrase enzymes

Dosage & Administration

• 0.5% eye drop for adults and children 1 year and older
• 1-2 drops every 2 hours for first 2 days
• 1-2 drops every 4 hours for days 3-7
• 1.5% eye drop for adults and children 6 years and older
• 1-2 drops every 30 minutes to 2 hours for days 1-3
• 1-2 drops every 1 to 4 hours from day 4 through treatment completion
• Not established for children under 1 year

Interaction

• Elevation of plasma concentrations of theophylline
• Interference with caffeine metabolism
• Enhancement of effects of warfarin and its derivatives

Contraindications

• Hypersensitivity to Levofloxacin or other quinolones
• Hypersensitivity to any of the components of this medication

Side Effects

• Transient blurred vision
• Fever
• Foreign body sensation
• Headache
• Transient ocular burning
• Ocular pain or discomfort
• Pharyngitis
• Photophobia
• Allergic reactions
• Lid edema
• Ocular dryness
• Ocular itching

Pregnancy & Lactation

• Pregnancy Category C
• Should be used during pregnancy only if potential benefit justifies the potential risk to the fetus
• Caution should be exercised when administered to a nursing mother

Precautions & Warnings

• Prolonged use may result in overgrowth of non-susceptible organisms
• Discontinue use and institute alternative therapy if superinfection occurs

Therapeutic Class

• 4-Quinolone preparations

Storage Conditions

• Protected from light
• Store in a cool (15°C-25°C) and dry place
• Keep out of reach of children

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