Isotrin 20 mg (Capsule)
Unit Price: ৳ 75.00 (1 x 10: ৳ 750.00)
Strip Price: ৳ 750.00
Medicine Details
Category | Details |
---|---|
Generic | Isotretinoin oral |
Company | Square pharmaceuticals plc |
Indications
- Severe acne treatment
- Nodular or conglobate acne treatment
- Acne at risk of scarring treatment
Pharmacology
- Alters cell cycle progress
- Reduces sebum production
- Prevents pore blockage
- Reduces acne bacteria growth
- Induces apoptosis in sebocytes
- Reduces comedone formation
- Reduces hyperkeratinization
Dosage & Administration
- Take with food once or twice daily
- Prescribed by physicians with retinoid expertise
- Starting dose of 0.5 mg/kg daily
- Therapeutic response and adverse effects are dose-related
- Dose ranges from 0.5-1.0 mg/kg per day
- Treatment duration depends on the individual dose
- Treatment course of 16-24 weeks
- Lower starting dose for severe renal insufficiency
- Not indicated for prepubertal acne
- Treatment may be continued at lower dose for intolerant patients
Interaction
- Additive adverse effects with vitamin A or its derivatives
- Decreased efficacy with microdosed progesterone
- Increased risk of local irritation with topical keratolytic agents
- Reduced efficacy with oxidizing agents like benzoyl peroxide
Contraindications
- Pregnancy or breastfeeding
- Hypersensitivity to Isotretinoin or excipients
- Hepatic insufficiency
- Excessively elevated blood lipid values
- Hypervitaminosis A
- Concomitant treatment with tetracyclines
Side Effects
- Dryness of skin
- Dryness of mucosae (e.g. lips, nasal, eyes)
- Infections like gram positive bacterial infection
- Blood and lymphatic system disorders like anaemia and thrombocytopenia
- Psychiatric disorders like depression and anxiety
- Eye disorders like conjunctivitis and blurred vision
- Hepatobiliary disorders like increased transaminase
- Skin and subcutaneous tissues disorders like pruritus and rash
- Musculo-skeletal and connective tissue disorders like arthralgia and myalgia
- Renal and urinary disorders like glomerulonephritis
- General disorders and administration site conditions like malaise
Pregnancy & Lactation
- Absolute contraindication in pregnancy
- Great risk of severe foetal malformations
- Increased risk of spontaneous abortion
- Contraindicated in nursing mothers due to potential adverse effects in child exposed via milk
Precautions & Warnings
- Comprehensive information on pregnancy prevention for female patients
- Medically supervised pregnancy tests prior to starting and during treatment
- Follow-up visits at 28 day intervals
- Appropriate contraceptive advice for male patients
- Precautions for donating blood, sun exposure, and chemical dermabrasion
- Monitoring and referral for psychiatric and skin reactions
- Caution in patients with diabetes, obesity, alcoholism, or lipid metabolism disorder
Therapeutic Class
- Oral retinoids for Acne
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children