Olatab 100 mg (Tablet)
Unit Price: ৳ 1,150.00 (3 x 10: ৳ 34,500.00)
Strip Price: ৳ 11,500.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | Eskayef pharmaceuticals ltd |
Title
- Olaparib Capsules
Categories
- Medicine
- Pharmaceuticals
- Cancer Therapy
Description
- Monotherapy for breast and ovarian cancer
- Inhibitor of PARP enzymes
- Absorption, distribution, metabolism, and excretion information
- Recommended dosage and administration
- Interaction with anticancer agents and other drugs
- Contraindications, side effects, precautions, and warnings
- Use during pregnancy and lactation
- Storage conditions
Dosage
- 400 mg orally twice daily
- Swallow capsule whole
- Dosing modifications for adverse reactions, CYP3A inhibitors, and renal impairment
- Pediatric use not established
Pharmacology
- Inhibitor of PARP1, PARP2, and PARP3 enzymes
- Inhibition of tumor cell growth
- Cytotoxicity involving PARP enzymatic activity and PARP-DNA complex formation
- Absorption, distribution, metabolism, and excretion details
Indications
- Monotherapy for deleterious or suspected deleterious gBRCAm, HER2-negative metastatic breast cancer
- Neoadjuvant, adjuvant, or metastatic setting
- Maintenance treatment for platinum-sensitive relapsed high-grade epithelial ovarian, fallopian tube, or primary peritoneal cancer
Interaction
- Potentiation of myelosuppressive toxicity with anticancer agents
- Effects on Olaparib plasma concentrations with CYP3A inhibitors and inducers
Contraindications
- Hypersensitivity to Olaparib or any ingredient
Side Effects
- Common serious adverse reactions including anemia
- Proportion of patients discontinuing due to adverse events
- Reported serious ADRs
Pregnancy & Lactation
- Potential fetal harm during pregnancy
- Unknown excretion in human milk
Precautions & Warnings
- Incidence of Myelodysplastic Syndrome/Acute Myeloid Leukemia
- Hematological toxicity monitoring
- Risk of pneumonitis
- No specific treatment for overdose
Overdose Effects
- No specific treatment established
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store below 30°C, protect from light
- Keep out of the reach of children