Buflex 1000 mg (Tablet)
Unit Price: ৳ 30.00 (2 x 10: ৳ 600.00)
Strip Price: ৳ 300.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nabumetone |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Relief of signs and symptoms of osteoarthritis
- Relief of signs and symptoms of rheumatoid arthritis
- Consideration of potential benefits and risks before use
- Lowest effective dose usage
Pharmacology
- Non-steroidal anti-inflammatory drug (NSAID)
- Exhibits anti-inflammatory properties
- Exhibits analgesic properties
- Exhibits antipyretic properties
- Mode of action is not fully known
- Inhibition of prostaglandin synthesis
Dosage & Administration
- Available in 500 mg & 750 mg tablets
- Available in 1000 mg tablet
- Administration: Oral
- Recommended starting dose: 1000 mg
- Recommended administration with or without food
- Maximum starting doses in patients with renal insufficiency
- Administration in pediatric patients not established
Interaction
- Diminished antihypertensive effect of ACE-inhibitors
- Consideration for concomitant use with ACE-inhibitors
Contraindications
- Known hypersensitivity to nabumetone or its excipients
- Contraindicated in patients with asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Contraindicated for peri-operative pain in the setting of coronary artery bypass graft surgery
Side Effects
- Gastrointestinal effects: diarrhea, dyspepsia, abdominal pain, constipation, flatulence, nausea, positive stool guaiac, dry mouth, gastritis, stomatitis, vomiting
- Central Nervous System effects: dizziness, headache, fatigue, increased sweating, insomnia, nervousness, somnolence
- Dermatologic effects: pruritus, rash
- Special Senses effects: tinnitus
- Miscellaneous effects: edema
Pregnancy & Lactation
- Pregnancy Category C
- No adequate, well-controlled studies in pregnant women
- Use during pregnancy only if clearly needed
- Use during third trimester not recommended
- Not recommended for use in nursing mothers
Precautions & Warnings
- Association with renal papillary necrosis and abnormal renal pathology
- Association with abnormal renal pathology during long-term administration to animals
- Risk factors for renal toxicity
- Discontinuation typically followed by recovery
Overdose Effects
- Symptoms of acute NSAIDs overdose
- Gastrointestinal bleeding
- Rare occurrence of hypertension, acute renal failure, respiratory depression, and coma
- Management by symptomatic and supportive care
- No specific antidotes
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs for Rheumatoid Arthritis
Storage Conditions
- Store in a cool and dry place
- Away from light & moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C15H16O2
Common Questions
- What is Buflex 1000 mg Tablet?
- Buflex 1000 mg Tablet usage
- Quick Tips for Buflex 1000 mg Tablet usage