Tacrograf 0.5 mg (Capsule)
Unit Price: ৳ 28.00 (3 x 10: ৳ 840.00)
Strip Price: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tacrolimus monohydrate oral |
| Company | Beacon pharmaceuticals plc |
| Also available as |
Indications
- Prophylaxis of organ rejection in adult and pediatric patients receiving allogeneic liver, kidney, heart, or lung transplants
Pharmacology
- Binds to intracellular protein FKBP-12
- Inhibits calcineurin's phosphatase activity
- Inhibits expression of various cytokines
- Inhibits T-lymphocyte activation and proliferation
Dosage & Administration
- Recommended oral starting doses
- Adult and pediatric dosage recommendations
- Whole blood trough concentration range for different transplant types
Interaction
- Interaction with mycophenolic acid products
- Interaction with nelfinavir and grapefruit juice
- Effects of CYP3A inhibitors and inducers
- Co-administration with cannabidiol
- Therapeutic drug monitoring and dose reduction considerations
Contraindications
- Hypersensitivity to tacrolimus or HCO-60 (polyoxyl 60 hydrogenated castor oil)
Side Effects
- Common adverse reactions including abnormal renal function, hypertension, diabetes mellitus, fever, tremor, hyperglycemia, leukopenia, infection, anemia, bronchitis, and more
Pregnancy & Lactation
- Potential risk to the fetus
Precautions & Warnings
- Not interchangeable with extended-release Tacrograf products
- Monitoring blood glucose for new onset diabetes after transplant
- Nephrotoxicity precautions
- Monitoring for neurologic abnormalities
- Monitoring serum potassium levels
- Considerations for hyperkalemia and hypertension
- Observation for anaphylactic reactions with IV formulation
- Not recommended for use with sirolimus
- Consideration for myocardial hypertrophy
- Avoidance of live vaccines
- Consideration for pure red cell aplasia
- Thrombotic microangiopathy and thrombocytopenic purpura precautions
Overdose Effects
- Reported acute overdosages
- Adverse reactions following acute overdosage
- Treatment options for acute overdoses
Therapeutic Class
- Drugs affecting the immune response
Storage Conditions
- Storage below 30°C
- Dry place away from light and moisture
- Keep out of the reach of children