Zyrolin 2 mg/ml (IV Infusion)

300 ml solution: ৳ 450.00

Medicine Details

Category Details
Generic Linezolid
Company Popular pharmaceuticals ltd
Also available as
Zyrolin 400 mg tablet Zyrolin 600 mg tablet Zyrolin 100 mg suspension

Title

  • Zyrolin

Categories

  • Antibacterial Agents
  • Oxazolidinones
  • Macrolides

Description

  • A synthetic, antibacterial agent with in vitro activity against Gram positive aerobic bacteria, some Gram positive anaerobic bacteria, and certain Gram negative bacteria.
  • Selectively inhibits bacterial protein synthesis via a mechanism of action different from that of other antibacterial agents.
  • Available in parenteral formulation for intravenous administration and oral presentation in the form of film-coated tablets and oral suspension.

Indications

  • Vancomycin-Resistant Enterococcus faecium infections
  • Nosocomial pneumonia caused by Staphylococcus aureus and Streptococcus pneumoniae
  • Complicated skin and skin structure infections including diabetic foot infections
  • Community-acquired pneumonia
  • Bacteremia

Pharmacology

  • Binds to the 23S ribosomal RNA of the 50S subunit of the bacterial ribosome
  • Prevents the formation of a functional 70S initiation complex
  • Bacteriostatic against enterococci and staphylococci
  • Bactericidal for the majority of streptococci strains

Dosage

  • Oral bioavailability of approximately 100%
  • Injection administered over a period of 30 to 120 minutes
  • Dosage varies for pediatric patients, adults, adolescents, and neonates
  • Recommended duration of treatment for different indications

Administration

  • Oral suspension reconstitution instructions
  • Intravenous administration guidelines
  • Storage recommendations for reconstituted suspension and infusion bottles

Interaction

  • Reversible and nonselective inhibitor of monoamine oxidase
  • Potential interaction with adrenergic and serotonergic agents
  • Enhancement of pressor response to adrenergic agents
  • Possible signs and symptoms of serotonergic syndrome with serotonergic agents

Contraindications

  • Known hypersensitivity to Linezolid or any of the product components
  • Concurrent use of monoamine oxidase inhibitors
  • Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome
  • Use with sympathomimetic, vasopressive, dopaminergic agents, serotonin re-uptake inhibitors, tricyclic antidepressants, and other specific medications

Side Effects

  • Mild to moderate adverse events
  • Common events include diarrhea, headache, and nausea
  • Other events such as oral and vaginal moniliasis, hypertension, dyspepsia, localized abdominal pain, pruritus, and tongue discoloration

Pregnancy & Lactation

  • Pregnancy Category C
  • Caution advised during lactation due to potential excretion in human milk

Precautions & Warnings

  • Monitoring for recurrent nausea or vomiting, unexplained acidosis, and low bicarbonate level
  • Observation for signs and symptoms of serotonin syndrome
  • Prompt ophthalmic evaluation if visual impairment symptoms occur
  • Risk of convulsions in some cases with a history of seizures or risk factors

Overdose Effects

  • No reported cases of overdose
  • Advised symptomatic and supportive care
  • Approximately 30% removal during 3 hours of haemodialysis

Therapeutic Class

  • Macrolides

Storage Conditions

  • Room temperature storage away from light and moisture
  • Keep out of reach of children

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