Zyrolin 100 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 280.00

Medicine Details

Category Details
Generic Linezolid
Company Popular pharmaceuticals ltd
Also available as
Zyrolin 400 mg tablet Zyrolin 600 mg tablet Zyrolin 2 mg injection

Indications

  • Vancomycin-Resistant Enterococcus faecium infections
  • Nosocomial pneumonia caused by Staphylococcus aureus
  • Complicated skin and skin structure infections
  • Uncomplicated skin and skin structure infections
  • Community-acquired pneumonia
  • Infections caused by Streptococcus pneumoniae

Pharmacology

  • Synthetic antibacterial agent
  • Belongs to oxazolidinones class of antibiotics
  • Inhibits bacterial protein synthesis
  • Bacteriostatic against enterococci and staphylococci
  • Bactericidal for streptococci

Dosage

  • Parenteral formulation
  • Oral presentation
  • Dosage adjustment not required for switch to oral
  • Consecutive days of treatment
  • Recommended duration of treatment
  • Oral bioavailability of approximately 100%

Administration

  • Reconstitution of Oral Suspension
  • Intravenous Administration
  • Shake the suspension well before each use
  • Storage of reconstituted suspension
  • Intravenous infusion over a period of 30 to 120 minutes

Interaction

  • Reversible and nonselective inhibitor of monoamine oxidase
  • Potential interaction with adrenergic and serotonergic agents

Contraindications

  • Known hypersensitivity to Linezolid
  • Contraindicated with monoamine oxidase inhibitors
  • Uncontrolled hypertension
  • Patients taking sympathomimetic agents

Side Effects

  • Mild to moderate adverse events
  • Common adverse events: diarrhea, headache, nausea
  • Other adverse events: hypertension, pruritus, dyspepsia

Pregnancy & Lactation

  • Pregnancy Category C
  • Caution during lactation

Precautions & Warnings

  • Monitoring for nausea, vomiting, and acidosis
  • Observation for signs of serotonin syndrome
  • Ophthalmic evaluation for symptoms of visual impairment
  • Risk of convulsions in patients with seizure history

Overdose Effects

  • No reported cases of overdose
  • Symptomatic and supportive care advised
  • Approximately 30% removal during 3 hours of haemodialysis

Therapeutic Class

Macrolides

Storage Conditions

  • Room temperature storage (15°C-30°C)
  • Protection from light and moisture
  • Keep away from children

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