Newxone 2 gm/vial (IV Injection)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ceftriaxone sodium |
| Company | Ad din pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Acute Bacterial Otitis Media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial Septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis of infections associated with surgery
Pharmacology
Ceftriaxone is a 3rd generation broad-spectrum parenteral cephalosporin antibiotic. It has potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms.
Dosage
- Adult: 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Infants and Children (01 month or older): 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day)
- Duration of therapy: 4 to 14 days; in complicated infections, longer therapy may be required
Administration
- Intramuscular Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Lidocaine HCI 1% injection.
- Intravenous Injection: 250 mg or 500 mg Ceftriaxone should be dissolved in Water for injection.
- Administration Time: Injection should be administered over 2-4 minutes or by tubing infusion over a period of 30 minutes.
- Fresh Solution Usage: The use of freshly reconstituted solution is recommended.
Interaction
No drug interactions have been reported.
Contraindications
Ceftriaxone should not be given to patients with a history of hypersensitivity to cephalosporin antibiotics.
Side Effects
- Diarrhea
- Nausea
- Vomiting
- Rash
- Pruritus
- Urticaria
- Eosinophilia
- Thrombocytopenia
- Leucopenia
- Anemia
- Local phlebitis rarely following intravenous administration
Pregnancy & Lactation
Its safety in human pregnancy has not been established. Caution should be exercised when Ceftriaxone is administered to a lactating mother.
Precautions & Warnings
- Anaphylactic shock cannot be ruled out
- Shadows suggesting sludge in the gallbladder have been detected
- Blood picture should be checked at regular intervals during prolonged treatment
Use in Special Populations
Newxone must not be given to neonates if the neonates is premature and newborn (up to 28 days of age)
Overdose Effects
There is no specific antidote. Treatment of overdosage should be symptomatic.
Therapeutic Class
Third generation Cephalosporins
Storage Conditions
Vial store in a cool, dry place (below 30°C), away from light & moisture. Keep out of the reach of children.