Admero 1 gm/vial (IV Injection or Infusion)

Indications

• Pneumonia and Nosocomial Pneumonia
• Urinary Tract Infections
• Intra-abdominal Infections
• Gynaecological Infections
• Skin and Skin Structure Infections
• Meningitis
• Septicaemia
• Pulmonary infections in cystic fibrosis
• Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

Bactericidal action by interfering with bacterial cell wall synthesis

Dosage

• Adults:
  • 500 mg to 1 gm by intravenous administration every 8 hours
  • 1 g IV every 8 hours for Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia
  • Upto 2 gm every 8 hours for Cystic fibrosis
  • 2 gm IV every 8 hours for Meningitis
• Children:
  • 10 to 40 mg/kg intravenously every 8 hours depending on type and severity of infection
  • 20 mg/kg every 8 hours for Intra-abdominal infections
  • 25-40 mg/kg every 8 hours for Cystic fibrosis
  • 40 mg/kg IV every 8 hours for Meningitis
  • 20 mg/kg every 8 hours for Febrile neutropenia

Administration

Intravenous Infusion over approximately 15-30 minutes or as intravenous bolus over approximately 3-5 minutes

Interaction

Probenecid competition for active tubular secretion, reduction of serum valproic acid levels

Contraindications

Hypersensitivity to the product

Side Effects

• inflammation
• thrombophlebitis
• pain at the site of injection
• skin reactions like rash, pruritus, urticaria
• abdominal pain
• nausea
• vomiting
• diarrhea
• headache

Pregnancy & Lactation

Category B, caution during breastfeeding

Precautions & Warnings

• Discontinue on allergic reaction
• Monitor transaminase and bilirubin levels in hepatic disease patients

Use in Special Populations

• Dosage adjustment for renal impairment
• Use with caution in nursing women
• No experience in children with hepatic or renal impairment
• Efficacy and tolerability in infants under 3 months not established

Overdose Effects

Symptomatic treatment; haemodialysis for renal impairment

Therapeutic Class

Other beta-lactam Antibiotics

Reconstitution

• Intravenous bolus Administration: Reconstitute with sterile water for injection
• Intravenous infusion administration: May be directly constituted with compatible infusion fluid and then further diluted with the compatible infusion fluid
• Compatible infusion fluids:
  • 0.9% sodium chloride intravenous infusion
  • 5% or 10% glucose intravenous infusion
  • 5% glucose intravenous infusion with 0.02% sodium bicarbonate
  • 5% glucose and 0.9% sodium chloride intravenous infusion
  • 5% glucose with 0.225% sodium chloride intravenous infusion
  • 5% glucose with 0.15% potassium chloride intravenous infusion
  • 2.5% and 10% mannitol intravenous infusion
  • normosol-M in 5% glucose intravenous infusion
• Storage Recommendation: Vial store in a cool, dry place (below 30°C), away from light & moisture

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