Montinex 10 mg (Tablet)

Title

• Montinex 10 mg Tablet

Categories

• Medicine
• Healthcare
• Pharmaceutical

Indications

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

• Selective and orally active leukotriene receptor antagonist
• Inhibits the cysteinyl leukotriene receptor (CysLT1)
• Correlated with the pathophysiology of asthma & allergic rhinitis
• Inhibits airway edema, smooth muscle contraction, and altered cellular activity associated with inflammation

Dosage & Administration

• 10 mg tablet once daily for adults and adolescents 15 years of age and older
• 5 mg tablet once daily for pediatric patients 6 to 14 years of age
• 4 mg tablet once daily for pediatric patients 2 to 5 years of age
• 4 mg oral granules once daily for pediatric patients 6 months to 5 years of age
• No dosage adjustment in patients with mild-to-moderate hepatic insufficiency or renal insufficiency
• Similar pharmacokinetic profile in elderly and younger adults

Interaction

• Administered with other asthma therapies without apparent increase in adverse reactions
• No clinically important effects on the pharmacokinetics of several drugs
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Phenobarbital decreased the AUC of Montinex approximately 40% following a single 10mg dose

Contraindications

• Hypersensitivity to any component of this product

Side Effects

• Common: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
• Uncommon: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
• Rare: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

• Crosses the placenta following oral dosing in rats and rabbits
• Use during pregnancy only if clearly needed
• Caution should be exercised when given to a nursing mother

Precautions & Warnings

• Not indicated for use in the reversal of bronchospasm in acute asthma attacks
• Appropriate rescue medication should be available
• Therapy can be continued during acute exacerbations of asthma
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
• Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Montinex

Overdose Effects

• No adverse experiences in the majority of overdosage reports
• Usual supportive measures to be employed in the event of overdose

Therapeutic Class

• Leukotriene receptor antagonists

Storage Conditions

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C35H36ClNO3S
• Chemical Structure Image URL: [URL]

Commonly Asked Questions

• What is Montinex 10 mg Tablet?
• What is it used for?
• How soon can the effect be observed?
• How long does the effect last?
• Should it be used empty stomach?
• What if a dose is missed?
• Any pregnancy warnings?
• General Instructions

Usage Usability

• Helps keep airways open and easy breathing
• Blocks leukotrienes for asthma and allergic rhinitis treatment
• Not a fast-acting rescue medicine for asthma attacks
• Can be taken with or without food

Pregnancy Warning

• Use during pregnancy only if clearly needed
• Exercise caution when given to a nursing mother

Age Specific Dosage

• Different dosage for adults, adolescents, and pediatric patients of different age groups

Drug Interactions

• Did not have clinically important effects on the pharmacokinetics of several drugs
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Appropriate clinical monitoring when potent cytochrome P450 enzyme inducers are co-administered

Dosage Adjustment

• No adjustment required in patients with mild-to-moderate hepatic insufficiency or renal insufficiency

Common Side Effects

• Diarrhoea, fever, headache, nausea, vomiting, skin reactions
• Akathisia, anxiety, depression, dizziness, drowsiness
• Angioedema, memory loss, palpitations, suicidal tendencies

Administration Instructions

• May be taken with or without food
• Should not be abruptly substituted for inhaled or oral corticosteroids
• Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm

Supportive Measures for Overdose

• Remove unabsorbed material from the gastrointestinal tract
• Employ clinical monitoring
• Institute supportive therapy, if required

Usual Age Group for Use

• Adults and adolescents 15 years of age and older
• Pediatric patients 6 to 14 years of age
• Pediatric patients 2 to 5 years of age
• Pediatric patients 6 months to 5 years of age

Interaction with Other Medications

• No clinically important effects on the pharmacokinetics of several drugs
• Used concomitantly with a wide range of commonly prescribed drugs without evidence of clinical adverse interactions
• Appropriate clinical monitoring when potent cytochrome P450 enzyme inducers are co-administered

Placenta Crossability

• Crosses the placenta following oral dosing in rats and rabbits

Asthma and Rhinitis Treatment

• Prophylaxis and chronic treatment of asthma
• Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
• Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Storage Recommendation

• Store in cool & dry place below 30°C
• Protect from light & moisture
• Keep out of reach of children

Molecular Formula

• C35H36ClNO3S

Related Brands

• Luxem 10 mg (Tablet) - c2c-pharma-ltd
• Monfast ODT 5 mg (Dispersible Tablet) - synovia-pharma-plc
• Monfast ODT 4 mg (Dispersible Tablet) - synovia-pharma-plc
• Monfast 10 mg (Tablet) - synovia-pharma-plc
• AirFlow 5 mg (Chewable Tablet) - ad-din-pharmaceuticals-ltd