Croma 10 mg (Tablet)

Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00

Medicine Details

Category Details
Generic Montelukast sodium
Company Sharif pharmaceuticals ltd
Also available as
Croma 4 mg tablet Croma 5 mg chewable tablet

Title

  • Croma 10 mg Tablet

Categories

  • Medicine
  • Healthcare
  • Pharmacology
  • Asthma Treatment

Indications

  • Prophylaxis and chronic treatment of asthma
  • Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
  • Relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis

Pharmacology

  • Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1)
  • Inhibition of cysteinyl leukotrienes (LTC4, LTD4, LTE4)
  • Correlation with the pathophysiology of asthma & allergic rhinitis
  • Contribution to signs and symptoms of asthma

Dosage & Administration

  • Dosage for adults and adolescents 15 years of age and older: Montelukast 10 mg tablet once daily
  • Pediatric dosage for patients aged 6 to 14 years: Montelukast 5 mg tablet once daily
  • Pediatric dosage for patients aged 2 to 5 years: Montelukast 4 mg tablet once daily
  • Pediatric dosage for patients aged 6 months to 5 years: Montelukast 4 mg oral granules once daily
  • Safety and efficacy in pediatric patients with asthma 6 months to 14 years of age
  • No dosage adjustment for mild-to-moderate hepatic insufficiency
  • No dosage adjustment for renal insufficiency
  • Similar pharmacokinetic profile and oral bioavailability in the elderly

Interaction

  • Administered with other therapies for prophylaxis and chronic treatment of asthma
  • No clinically important effects on the pharmacokinetics of specified drugs
  • Used concomitantly with commonly prescribed drugs without evidence of clinical adverse interactions
  • Clinical monitoring recommended when co-administered with potent cytochrome P450 enzyme inducers

Contraindications

  • Hypersensitivity to any component of the product

Side Effects

  • Common side effects: Diarrhoea, fever, gastrointestinal discomfort, headache, nausea, vomiting, skin reactions, upper respiratory tract infection
  • Uncommon side effects: Akathisia, anxiety, arthralgia, asthenia, abnormal behavior, depression, dizziness, drowsiness, dry mouth, haemorrhage, irritability, malaise, muscle complaints, oedema, seizure, abnormal sensation, sleep disorders
  • Rare side effects: Angioedema, concentration impaired, disorientation, eosinophilic granulomatosis with polyangiitis, erythema nodosum, hallucination, hepatic disorders, memory loss, palpitations, pulmonary eosinophilia, suicidal tendencies, tremor

Pregnancy & Lactation

  • Crosses the placenta following oral dosing in rats and rabbits
  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy only if clearly needed
  • Caution should be exercised when given to a nursing mother

Precautions & Warnings

  • Not indicated for use in the reversal of bronchospasm in acute asthma attacks
  • Appropriate rescue medication should be available
  • Croma can be continued during acute exacerbations of asthma
  • Should not be abruptly substituted for inhaled or oral corticosteroids
  • Not to be used as monotherapy for the treatment and management of exercise induced bronchospasm
  • Caution for patients with known aspirin sensitivity
  • No evidence shown to truncate bronchoconstrictor response to aspirin and other non-steroidal anti-inflammatory drugs in aspirin-sensitive asthmatic patients

Overdose Effects

  • No adverse experiences in majority of overdosage reports
  • Frequent adverse experiences consistent with the safety profile of Croma
  • Usual supportive measures recommended in case of overdose

Therapeutic Class

  • Leukotriene receptor antagonists

Storage Conditions

  • Store in cool & dry place below 30°C
  • Protect from light & moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C35H36ClNO3S

Common Questions

  • What is Croma 10 mg Tablet?
  • What is Croma 10 mg Tablet used for?
  • How soon can the effect of Croma 10 mg Tablet be observed?
  • How long does the effect of Croma 10 mg Tablet last?
  • Should I use Croma 10 mg Tablet empty stomach?
  • What if I miss a dose of Croma 10 mg Tablet?
  • Are there any pregnancy warnings for Croma 10 mg Tablet?
  • General Instructions: Take Croma 10 mg Tablet exactly as prescribed by your doctor, etc.

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