Molukat 5 mg (Chewable Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Montelukast sodium |
| Company | Kemiko pharmaceuticals ltd |
| Also available as |
Title
Molukat 5 mg Chewable Tablet
Categories
- Asthma Medication
- Allergic Rhinitis Medication
- Leukotriene Receptor Antagonist
Description
Molukat 5 mg Chewable Tablet is indicated for prophylaxis and chronic treatment of asthma, acute prevention of Exercise-Induced Bronchoconstriction (EIB), and relief of symptoms of Allergic Rhinitis (AR): Seasonal & Perennial Allergic Rhinitis. It is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The recommended dosage for adults and adolescents with asthma or seasonal allergic rhinitis is Montelukast 10 mg tablet once daily. The safety and efficacy of Montelukast have been established in pediatric patients with asthma 6 months to 14 years of age. Montelukast is contraindicated in patients who are hypersensitive to any component of this product. Common side effects may include diarrhea, fever, headache, and nausea, among others. Molukat should be stored in a cool & dry place below 30°C, protected from light & moisture. It should be kept out of reach of children.
Indications
- Prophylaxis and chronic treatment of asthma
- Acute prevention of Exercise-Induced Bronchoconstriction (EIB)
- Relief of symptoms of Allergic Rhinitis: Seasonal & Perennial Allergic Rhinitis
Pharmacology
Montelukast is a selective and orally active leukotriene receptor antagonist that inhibits the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes and leukotriene receptor occupation have been correlated with the pathophysiology of asthma & allergic rhinitis, including airway edema, smooth muscle contraction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.
Dosage & Administration
- Adults and Adolescents:
- Montelukast 10 mg tablet once daily
- Pediatric Patients:
- 6-14 years: Montelukast 5 mg tablet once daily
- 2-5 years: Montelukast 4 mg tablet once daily
- 6 months-5 years: Montelukast 4 mg oral granules once daily
- Use in pediatric patients: The safety and efficacy of Montelukast have been established in this age group similar to those seen in adults
Interaction
Molukat has been administered with other therapies routinely used in the prophylaxis and chronic treatment of asthma with no apparent increase in adverse reactions. In drug interaction studies, the recommended clinical dose of Molukat did not have clinically important effects on the pharmacokinetics of various drugs. Phenobarbital, which induces hepatic metabolism, decreased the AUC of Molukat approximately 40% following a single 10mg dose of Molukat. No dosage adjustment for Molukat is recommended.
Contraindications
Montelukast is contraindicated in patients who are hypersensitive to any component of this product.
Side Effects
- Common:
- Diarrhea
- Fever
- Gastrointestinal discomfort
- Headache
- Nausea
- Vomiting
- Skin reactions
- Upper respiratory tract infection
- Uncommon:
- Akathisia
- Anxiety
- Arthralgia
- Asthenia
- Depression
- Dizziness
- Drowsiness
- Dry mouth
- Irritability
- Malaise
- Muscle complaints
- Edema
- Seizure
- Abnormal sensation
- Sleep disorders
- Rare:
- Angioedema
- Impaired concentration
- Disorientation
- Eosinophilic granulomatosis with polyangiitis
- Erythema nodosum
- Hallucination
- Hepatic disorders
- Memory loss
- Palpitations
- Pulmonary eosinophilia
- Suicidal tendencies
- Tremor
Pregnancy & Lactation
Montelukast crosses the placenta following oral dosing in rats and rabbits. There are no adequate and well-controlled studies in pregnant women. Because many drugs are excreted in human milk, caution should be exercised when Montelukast is given to a nursing mother.
Precautions & Warnings
Molukat is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmaticus. Patients should have appropriate rescue medication available. Molukat should not be abruptly substituted for inhaled or oral corticosteroids. It should not be used as monotherapy for the treatment of exercise induced bronchospasm. Patients with known aspirin sensitivity should continue avoidance of aspirin or non-steroidal anti-inflammatory agents while taking Molukat.
Overdose Effects
The most frequently occurring adverse experiences in the majority of overdosage reports were consistent with the safety profile of Molukat and included abdominal pain, somnolence, thirst, headache, vomiting, and psychomotor hyperactivity.
Therapeutic Class
Leukotriene receptor antagonists
Storage Conditions
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
Chemical Structure
- Molecular Formula: C35H36ClNO3S
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-768-montelukast-sodium-chemical-structure-drK1lRHjspWQ7613gJoZ.svg
Common Questions
- What is Molukat 5 mg Chew. Tablet?: Molukat 5 mg Chew. Tablet is a selective and orally active leukotriene receptor antagonist.
- What is Molukat 5 mg Chew. Tablet used for?: Molukat 5 mg Chew. Tablet is commonly used to treat asthma or allergic rhinitis. It helps keep airways open and easy breathing by blocking leukotrienes.
- How soon can the effect of Molukat 5 mg Chew. Tablet be observed?: The effect of Molukat 5 mg Chew. Tablet can be observed after 1-3 hours of administration. Molukat 5 mg Chew. Tablet is not a fast-acting rescue medicine for asthma attacks and needs to be taken daily to work properly.
- How long does the effect of Molukat 5 mg Chew. Tablet last?: The effect of Molukat 5 mg Chew. Tablet lasts for an average duration of 24 hours.
- Should I use Molukat 5 mg Chew. Tablet empty stomach?: Molukat 5 mg Chew. Tablet may be taken with or without food as prescribed by your doctor.
- What if I miss a dose of Molukat 5 mg Chew. Tablet?: If you miss a dose, you may take it as soon as possible. But if it is almost time for your next dose, just skip that dose. Do not double up on doses.
- Are there any pregnancy warnings for Molukat 5 mg Chew. Tablet?: Use of Molukat 5 mg Chew. Tablet in pregnant women should be avoided unless clearly needed.
- General Instructions:
- Take Molukat 5 mg Chew. Tablet exactly as prescribed by your doctor.
- Do not change your Molukat 5 mg Chew. Tablet dose or stop using asthma medication without your doctor's advice.
- Molukat 5 mg Chew. Tablet is not a fast-acting rescue medicine for asthma attacks. Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working.
- Avoid situations or activities that may trigger an asthma attack.
- Talk to your doctor before using Molukat 5 mg Chew. Tablet if you're pregnant or breastfeeding. They can help you decide if it's the right choice for you.